Relapse prevention represents the primary therapeutic challenge in the treatment of drug addiction. As with humans, drug-seeking behaviour can be precipitated in laboratory animals by exposure to a small dose of the drug (prime). The aim of this study was to identify brain nuclei implicated in the cocaine-primed reinstatement of a conditioned place preference (CPP). Thus, a group of mice were c...

Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 c...

In order to further investigate the role of the mPFC in morphine reward and drug priming induced relapse, the present study examined the effects of the mPFC lesions on the acquisition and morphine priming induced reinstatement of conditioned place preference (CPP). In the first experiment, mice received sham or bilateral kainic acid lesions of the mPFC and were subsequently tested for the acqui...

In rodents, a conditioned place preference (CPP) can be induced by morphine. In the current study, we designed a biased place conditioning paradigm to test the rewarding effects of morphine in freely moving rhesus monkeys. Five monkeys were first placed in three serial rooms with the doors open between them for three days. After this habituation period, during which baseline preference for each...

A main challenge in the therapy of drug dependent individuals is to help them reactivate interest in non-drug-associated activities. We previously developed a rat experimental model based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of social interaction with a gender- and weight-matched male Sprague Dawley rat (1) reversed CPP from cocaine to social int...

Conditioned place preference (CPP) is a learning paradigm requiring formation of associations between reward and particular locations. White and McDonald (Behav Brain Res 1993;55:269-281) demonstrated that amygdala (AMG) lesions impair, while fornix (Fx) lesions enhance learning of this task. In the present experiments, we replicated the effects of AMG and Fx lesions, but we also found that com...

Neurotensin is one of the genes previously found up-regulated in mice striatum after acute injection of MDMA (9 mg/kg). In order to examine the pharmacological significance of this effect, the involvement of the neurotensinergic system in MDMA-induced behaviors was explored in mice using the neurotensin receptor antagonist SR142948A (1mg/kg). We found that acute administration of the antagonist...

The present study examined the rewarding properties of 4-androsten-17beta-ol-3-one testosterone in intact male mice using the conditioned place preference (CPP) technique. In Experiment 1, the pharmacokinetics of 0.8 and 1.2 mg/kg of testosterone were studied to determine the most appropriate temporal interval to test behavior. Additionally, the locomotor activity was recorded to control a poss...

objective: it has been shown that berberine, a major component of berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (da) and n-methyl-d-aspartate (nmda) contributing to rewarding and reinforcing effects of morphine. drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. in the p...

the effect of hypericin on the expression of morphine-induced conditioned place preference (cpp) was investigated and compared with the effect of the synthetic antidepressants. the cpp paradigms took place over six days using an unbiased procedure. the results demonstrate that intra-peritoneal (ip) injection of morphine sulfate (2.5, 5 and 10 mg/kg) significantly induce the cpp in rat. intra-pe...