Specialized proteins in the plasma membrane, endoplasmic reticulum (ER), and mitochondria tightly regulate intracellular calcium. A unique mechanism called store-operated calcium entry is activated when ER calcium is depleted, serving to restore intra-ER calcium levels. An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates within the ER membrane upon store depletion to the ...

Hydroxyapatite (HA), a material proven to be biocompatible within the human body, has been produced to a high level of purity. This material has been applied as a coating on Ti-6Al-4V alloy by using the air plasma spraying technique. The coat was characterizted with SEM, XRD, FTIR and Raman spectroscopy methods to consist of a mixture of calcium phosphates including HA mainly and traces of tric...

1. The bivalent cation-binding agent, cellulose phosphate, was given for 6 days to four normal subjects and six patients with latent hypoparathyroidism (diagnosed by impaired response to EDTA infusion), all of whom were on a moderately low calcium diet. 2. In normal subjects, there was a prompt and sustained fall in urinary calcium with no change in plasma calcium, indicating increased tubular ...

1. Chronic administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] can normalize plasma calcium in human hypoparathyroidism and in thyroparathyroidectomized animals. The effect of 1,25(OH)2D3 on plasma calcium is associated with an increase in urinary calcium excretion. In an attempt to prevent this increase thyroparathyroidectomized rats receiving 1,25(OH)2D3 were also treated with hydrochlor...

In vivo studies in rats demonstrated that acute intragastric administration of ethanol (3 g/kg BW) resulted in a reduced net absorption of fluid and calcium. Thirty minutes after an i.v. injection of 2 microCi 45Ca, the gastrointestinal 45Ca content in ethanol-treated rats was significantly higher than in controls indicating an increase in calcium secretion. The effect of ethanol on calcium mov...

The isolation and characterization of a plasma membrane preparation from rat heart is described. Enzymatic, chemical, and electron microscopic analysis revealed a relative lack of contamination with nuclear, mitochondrial, ribosomal, and sarcoplasmic reticulum membrane. One calcium binding site (I& = 265 pM, B,,, = 65 nmoIes/mg protein) was detected by equilibrium diaiysis. Monovalent metal ion...

OBJECTIVE To investigate associations between plasma calcium and future incidence of hypertension in a healthy population. METHODS We used prospective data from Ansung and Ansan cohorts (n = 10,038) of the Korean Genome and Epidemiology Study. Data from baseline (2001-02) to the fourth study (2007-08) were used. After excluding hypertensive cases at baseline, missing data, and outliers, 5560 ...

1. Sodium phosphate was infused intravenously over approximately 2+ h and produced a mean linear rise in plasma phosphorus levels of 9.1 mg/100 ml. Twentyone infusions were performed in twelve control subjects and thirty-eight were carried out in thirty-two patients with disorders of calcium and phosphorus metabolism. 2. The fall in plasma calcium under these conditions was related to: a. The i...

background: obesity is caused by several factors while sedentary lifestyle and excessive energy intake are the most important ones. obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity. studying serum calcium level, albumin, and triglyceride concentrations, we searched for probable correlation between serum calcium level and anthropometric data of t...