The first application of platelet-rich plasma (PRP) unveiled by Ferrari in 1987 as an autologous component after an open heart surgery [1]. Now there are at least five thousands registration in National Center for Biotechnology Information (NCBI) concerning PRP in various medical disciplines like orthopedic surgery, sports medicine, physical medicine, dentistry, neurosurgery, ophthalmology, uro...

Editorial Platelet rich plasma (PRP), also termed autologous platelet gel, plasma rich in growth factors (PRGF), platelet concentrate (PC), is essentially an increased concentration of autologous platelets suspended in a small amount of plasma after centrifugation. Basically, patient's blood is collected and centrifuged at varying speeds until it separates into 3 layers: platelet poor plasma (P...

OBJECTIVE To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both. METHODS Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the e...

By Gsaw n ALTSCHULER, AARON J. MARcus AND H uims L. Uu i N I HE HEMORRHAGIC tendency which develops in uremia is a well recognized clinical entity but the pathogenesis of this complication is not understood.’ In the past defective blood coagulation2 as well as increased vascular fragility3 have been suggested. The possibility of a functional blood platelet abnormality was first noted by Lewis, ...

Platelet phospholipids undergo significant alterations during aggregation induced by thrombin or other agents. There is an early increase in phosphatidic acid, with a decrease in phosphatidyl inositol. De novo synthesis of most phospholipids from 14C-glycerol is decreased. Thrombin stimulates 32P-phosphate incorporation into di- and triphosphoinositides, suggesting increased phosphorylation of ...

collected into the sodium citrate-containing tube, which showed normal platelet counts. Only a few cases of PGPS have been reported [1-4]. To our knowledge, this is the first case to be reported in Korea. Stavem and Berg [1] described EDTA-induced ‘platelet stain preventing factor’, and Mant et al. [2], Cockbill et al. [3], and Toyota et al. [4] reported platelet degranulation caused by EDTA. U...

The influence of an amide of prostaglandin E1 and ethanolamine plasmalogen platelet-activating factor analog 1-O-alk-1;-enyl-2-acetyl-sn-glycero-3-phospho-(N-11alpha, 15alpha-dioxy-9-keto-13-prostenoyl)ethanolamine (PGE1-PPAF) on platelet-activating factor (PAF)-, ADP-, and thrombin-induced human platelet aggregation has been studied. It was found that PGE1-PPAF inhibits the PAF-, ADP-, and thr...

The effect of oestrogen-containing compounds on platelet factor 3, platelet life span, renal platelet localization and the fibrinolytic activity of forearm venous blood has been studied in eleven women with the renal vascular abnormalities of the loin pain and haematuria syndrome. The results were compared with those obtained in twenty-nine healthy female volunteer subjects. 2. Platelet factor ...