For biodegradable polymers such as poly (Llactic acid) (PLLA), material crystallinity has a considerable effect on degradation and physical properties. In this work, the effects of laser fluence of a 355 nm UV Q-switched Nd-YAG laser on the crystallinity and conformation at the surface of PLLA films and the factors affecting the transformation are investigated. Electron microscopy, X-ray diffra...

The delivery of noscapine therapies directly to the site of the tumor would ultimately allow higher concentrations of the drug to be delivered, and prolong circulation time in vivo to enhance the therapeutic outcome of this drug. Therefore, we sought to design magnetic based polymeric nanoparticles for the site directed delivery of noscapine to invasive tumors. We synthesized Fe(3)O(4) nanopart...

Previously, we have developed a novel porous hydroxyapatite/poly l-lactic-co-caprolactone (HA/PLCL) composite sandwich beam as new scaffold material for bone regeneration. This work presents the study of bending fracture mechanisms and microdamage L-lactic-acid (HA/PLLA) beam, in comparison to previous HA/PLCL beam. Both beams were fabricated using method which single layered between two polyme...

The essence of tissue engineering is the fabrication of autologous cells or induced stem cells in naturally derived or synthetic scaffolds to form specific tissues. Polymer is thought as an appealing source of cell-seeded scaffold owing to the diversity of its physicochemical property and can be electrospun into nano-size to mimic natural structure. Poly (L-lactic acid) (PLLA) and poly (ε-capro...

Design of mechanical skeletons of biodegradable synthetic polymers such as poly(L-lactic acid) (PLLA), poly(DL-lactic-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL) is important in the construction of the hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers such as collagen. In this study, cylinder-shaped PLLA, PLGA, and PCL sponges were prepared by the ...

Linli Zhang, Shiyun Meng, Ze Zhang Faculty of Medicine, Laval University; Saint-François d’Assise Hospital Research Center, CHUQ, Quebec, QC, Canada. Statement of Purpose: Polypyrrole (PPy) is an important intrinsically conducting polymer studied for tissue engineering and bioelectrical applications. Its composites with biodegradable polylactide (PLLA) can be used as substrate for electrically ...

Stereocomplex poly(lactide) (PLA) was obtained by solution blending of linear PLLA and PDLA-PEG-PDLA. Effects of the L/D ratios, PEG block, and PDLA block on stereocomplexation of the blends are systemically discussed. The full stereocomplex PLA can be acquired by solution blending when L/D ratios are in the range of 7/3–5/5. The experiment results demonstrated that the stereocomplex degree of ...

Poly-L-lactic acid (PLLA) is a synthetic injectable medical agent used to treat patients with loss of volume in the face, chest, and hands. It consists of a biodegradable and bioresorbable powder, a synthetic nonpermanent polymer. PLLA was introduced in Europe in 1999 (NewFill; Ashford Aesthetics Inc., Brussels, Belgium) under the category of wrinkle filler [1]. The Food and Drug Administration...

Radiation therapy for cancer in the head and neck region leads to a marked loss of salivary gland parenchyma, resulting in a severe reduction of salivary secretions. Currently, there is no satisfactory treatment for these patients. To address this problem, we are using both tissue engineering and gene transfer principles to develop an orally implantable, artificial fluid-secreting device. In th...

Dissipative particle dynamics (DPD), a mesoscopic simulation approach, has been used to investigate the chain length effect on the structural property of the immiscible polyethylene (PE)/poly(L-lactide) (PLLA) polymer in a polymer blend and in a system with their diblock copolymer. In this work, the interaction parameter in DPD simulation, related to the Flory-Huggins interaction parameter chi,...