A significant survival difference between black and white breast cancer patients has been observed in the United States. Evaluation of the prognostic value of DNA ploidy and S-phase fraction (SPF) in black and white breast cancer patients may contribute to our understanding of the mechanisms of racial disparity in survival. A sample of 98 patients (50 blacks and 48 whites) who participated in t...

Megakaryocytes (MKs) from 40 patients with quantitative platelet disorders and 19 normal volunteers were analyzed by flow cytometry for size, fine cell internal structure and granularity, membrane expression of the glycoprotein (GP) IIb/IIIa complex, and for ploidy distribution. Analysis was performed on unfractionated minimally manipulated marrows obtained from routine bone marrow aspirates. M...

Ploidy and Allelic Variation Affects Fungal Pathogen Virulence in a Nematode Host By Dorian J. Feistel Genotype-by-genotype interactions between hosts and pathogens can play a significant role in determining pathogen virulence. In addition to allelic variation, ploidy is an important component of an individual genotype. Thus, the relative contributions of pathogen ploidy and allelic composition...

In their study of the DNA levels (ploidy) of murine megakaryocyte colonies, Chatelain and Burstein evaluated the effects of acute thrombocytopenia upon the ploidy of megakaryocyte colonies derived from mice that had received platelet antiserum.’ They reported that colonies derived from bone marrow, obtained 24 hours after the administration of platelet antiserum, demonstrated the same ploidy di...

BACKGROUND Because 80% of cervical cancers arise in low-resource settings, many inexpensive strategies are being tested. In that spirit, the authors are testing large-scale genomic or DNA ploidy measurements as an inexpensive and semiautomated strategy. METHODS Patients entered either a screening or diagnostic study of several optical technologies: quantitative cytology, quantitative histopat...

Ploidy level affects cell size in many organisms, and ploidy-dependent cell enlargement has been used to breed many useful organisms. However, how polyploidy affects cell size remains unknown. Previous studies have explored changes in transcriptome data caused by polyploidy, but have not been successful. The most naïve theory explaining ploidy-dependent cell enlargement is that increases in gen...

BACKGROUND AND AIMS Detailed knowledge of variations in ploidy levels and their geographic distributions is one of the key tasks faced in polyploid research in natural systems. Flow cytometry has greatly facilitated the field of cytogeography by allowing characterization of ploidy levels at both the regional and population scale, and at multiple stages of the life cycle. In the present study, f...