Genomic analysis of the Chlamydiaceae has revealed a multigene family encoding large, putatively autotransported polymorphic membrane proteins (Pmps) with nine members in the sexually transmitted pathogen Chlamydia trachomatis. While various pathogenesis-related functions are emerging for the Pmps, observed genotypic and phenotypic variation among several chlamydial Pmps in various Chlamydia sp...

Cancer cells aberrantly express mucins to enhance their survival. Relative chemoresistance of appendiceal pseudomyxoma peritonei (PMP) is attributed to abundant extracellular mucin 2 (MUC2) protein production. We hypothesized that simultaneous MUC2 inhibition and apoptosis induction would be effective against mucinous tumors. In vitro studies were conducted using LS174T cells (MUC2-secreting hu...

AIMS Microparticles (MP) are cell-derived fragments known to be increased in the blood of patients with acute coronary syndromes. We aimed to assess, in ST elevation myocardial infarction (STEMI), the systemic and local (in the culprit coronary artery) levels of platelet-derived MP (PMP, CD42+CD31+) and endothelial-derived MP (EMP, CD42-CD31+) and their relation to indexes of microvascular obst...

The aims of this study were to determine the frequency dialysis and kidney transplantation estimate regularity comprehensive conservative management (CCM) for patients with failure in Europe. This uses data from ERA-EDTA Registry. Additionally, our included supplemental Armenia, Germany, Hungary, Ireland, Kosovo, Luxembourg, Malta, Moldova, Montenegro, Slovenia additional Israel, Italy, Slovaki...

Prescription drug abuse is an epidemic that will not be controlled without a well-coordinated effort. Prescribers in Rhode Island can contribute substantively to this effort by using the Rhode Island Prescription Drug Monitoring Program (“PMP”) consistently. The PMP is a simple on-line tool that helps prescribers monitor patient-prescription histories. Every prescription filled in the state is ...

Probable Maximum Precipitation (PMP) is an essential prerequisite in designing dams, spillways, and reservoirs in order to minimize the risk of overtopping infrastructure collapse, especially under today’s changing climate. This study investigates conventional PMP estimation approach by using both scarce in-situ observations and mainstream satellite precipitation products in the Dadu River basi...

In vivo pulmonary arterial catheterization was used to determine the mechanism by which platelet-activating factor (PAF) produces pulmonary edema in rats. PAF induces pulmonary edema by increasing pulmonary microvascular permeability (PMP) without changing the pulmonary pressure gradient. Rats were cannulated for measurement of pulmonary arterial pressure (Ppa) and mean arterial pressure. PMP w...

BACKGROUND UK native renal biopsy incidence is unknown. Biopsy registries in other countries indicate that the incidence of renal biopsy varies widely. Indications for renal biopsy are largely opinion based. METHODS The Scottish Renal Biopsy Registry aimed to analyse the incidence of native renal biopsy in Scotland and examine indications and diagnoses obtained where practice varied widely. ...

INTRODUCTION This chapter describes the characteristics of adult patients starting renal replacement therapy (RRT) in the UK in 2010 and the incidence rates for RRT in Primary Care Trusts and Health Boards (PCT/HBs) in the UK. METHODS The basic demographics and clinical characteristics are reported on patients starting RRT from all UK renal centres. Presentation time, defined as time between ...