BACKGROUND The surfactant poloxamer 188 (P188) has been shown to improve survival following hemorrhage. This study used P188 as a small volume resuscitation product in a sedated, sexually mature, male miniature swine severe hemorrhage model for potential improvement in rate and time of survival. METHODS Fourteen swine were anesthetized, catheterized for hemorrhage and resuscitation and allowe...

The aim of this study was to investigate the effect of different carriers on solubility and in vitro dissolution of poorly water soluble drug meloxicam (MLX). Solid dispersions with Polyethylene glycol-6000 (PEG6000), Poloxamer 188 (Plx188), Poloxamer 407 (Plx407) and inclusion complexes (ICs) with β cyclodextrin (β-CD) were prepared by different methods in three different weight ratios. All SD...

The aim of the work was to enhance dissolution rate rivaroxaban by preparing its solid dispersions (SDs) using hydrophilic carrier poloxamer 188. prepared were characterized Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Both solubility drug in these formulations increased. SDs with 188 at 1:1, 1:2 1:3 w/w ratios physical mixing, melting solvent evap...

OBJECT The surfactant, poloxamer 188 (P-188), has been found to protect against tissue injury in various experimental models. Its protective mechanism may involve the effects of the surfactant against oxidative stress and inflammation. The authors investigated the role of P- 188 in the reduction of tissue injury and macrophage response in a model of excitotoxic brain injury in the rat striatum....

Melittin is the main effective component of bee venom and has extensive biological functions; however, serious side effects have restricted its clinical application. Preclinical and clinical studies showed that the main adverse events were allergic reaction and pain at the administration site. To decrease the toxicity, we prepared melittin nano-liposomes by encapsulating melittin with poloxamer...

In mucosal tissues, epithelial M cells capture and transport microbes across the barrier to underlying immune cells. Previous studies suggested that high affinity ligands targeting M cells may be used to deliver mucosal vaccines; here, we show that particle composition and dispersion buffer ionic strength can independently influence their uptake in vivo. First, addition of a poloxamer 188 to na...

DESCRIPTION PROGLYCEM (diazoxide) is a nondiuretic benzothiadiazine derivative taken orally for the management of symptomatic hypoglycemia. PROGLYCEM Capsules contain 50 mg diazoxide, USP. The Suspension contains 50 mg of diazoxide, USP in each milliliter and has a chocolatemint flavor; alcohol content is approximately 7.25%. Other ingredients: Sorbitol solution, chocolate cream flavor, propyle...