Thermoreversible polymer hydrogels (TRGs) are physical aqueous networks triggered by temperature that find potential applications in tissue engineering (TE) and drug/gene delivery. When systems with lower critical solution (LCST) behaviour used, the of is mixed cells or drugs/genes, depending on desired application, at room then injected vivo to form a hydrogel. This situ forming hydrogel acts ...

Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants in biotherapeutics formulations, typically non-ionic polymeric ether surfactants. The most commonly used examples are Tween 20 (Polysorbate 20...

Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Pluronics or Poloxamers) can self-assemble into various nanostructures in water and its mixtures with polar organic solvents. Ethylammonium nitrate (EAN) is a well-known protic ionic liquid that is expected to affect amphiphile self-assembly due to its ionic nature and hydro...

BACKGROUND Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 and TPGS may increase the therapeutic efficacy of the drug by d...

A facile procedure to fabricate the hydrophobic surfaces of calcium carbonate-polymer composites has been well described. Nano-sized highly ordered CaCO3 clusters i.e. calcite/vaterite have been synthesized by simple precipitation in the presence of template made of cationic surfactant: cetyl trimethyl ammonium bromide (CTAB) and different non-ionic amphiphilic triblock copolymers comprising of...

For spinal fusions and the treatment of non-union fractures, biological substrates, scaffolds, or carriers often are applied as a graft to support regeneration of bone. The selection of an appropriate material critically influences cellular function and, ultimately, patient outcomes. Human bone marrow mesenchymal stem cells (BMSCs) are regarded as a critical component of bone healing. However, ...

Introduction. Periprosthetic infections are a major problem in orthopedic surgery. The most optimal way to influence the bacterial film is suppress early stages of its formation. use hydrogel coatings for prevention periprosthetic an effective measure, while process coating implant can be simplified due situ systems. Aim. purpose research develop and study antibacterial preoperative treatment i...

Aqueous solutions of a Pluronic copolymer P104 have been investigated by rheological techniques in order to characterize its gelation and its gel properties. P104 solutions have a low viscosity at low temperatures but form an elastic gel at physiological temperatures. Elastic moduli are of the order 10 kPa with a significant yield stress. Possible use of P104 to prevent flow in pipes or blood v...

Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin are widely used drugs for the treatment of hepatitis C virus, have poor bioavailability due to their low aqueous solubility that limits their dissolution rates. To overcome these limitations solid dispersions (SDs) and self-microemulsifing drug delivery systems (SMEDDS) were prepared in an attempt to improve their release profile. SDs were pre...