In the title compound, [Zn(C(17)H(14)Cl(2)N(3)O(3)S)(2)(H(2)O)(2)], the Zn(II) ion has a tetra-hedral coordination formed by the two N atoms of the sulfonamide groups and the two water mol-ecules. Two inter- and two intra-molecular O-H⋯O hydrogen bonds are observed in the crystal structure.

The bacteriostatic action of 2-chloro-4-aminobenzoic acid (2-Cl-PAB) was found by Wyss, Rubin, and Strandskov (1943) to be completely reversed by p-aminobenzoic acid. This, according to the theory of Woods (1940) that p-aminobenzoic acid is a specific antagonist for sulfanilamide, classified the bacteriostatic action of 2-Cl-PAB as sulfonamide activity. The bacteriostatic action of this compoun...

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the in...

The mechanism whereby sulfanilamide and its derivatives prevent bacterial growth is not known. None of the various theories advanced (1-3) has been conclusively substantiated by direct experimental proof. The most important recent contribution to the problem has been that of Woods (4), who demonstrated that p-aminobenzoic acid "blocks" the bacteriostatic effect of sulfanilamide in vitro. Follow...

In this study, we synthesized a novel multifunctional benzoxazine monomer (Coumarin-COOH BZ), possessing both coumarin and COOH groups, through the reaction of 4-methyl-7-hydroxycoumarin, 4-aminobenzoic acid, and paraformaldehyde in 1,4-dioxane, with the structure confirmed using 1H and 13C nuclear magnetic resonance and Fourier transform infrared (FTIR) spectroscopy. Differential scanning calo...

Analytical recovery of urinary p-aminobenzoic acid liberated from bentiromide(N-benzoyl-L-tyrosyl-p-aminobenzoicacid) was determinedby roomtemperaturephosphorimetryas an index to exocrine pancreatic function. Metabolites were hydrolyzed to the parent compound in 4 mol/L NaOH, then quantified, after pH adjustment, by spothng 3 L of this solution onto filter paper treated with potassium iodide an...

705 706 708 Reversal of p-Aminobenzoic Acid Inhibition of Growth of Rickettsiae by p-Hydroxybenzoic Acid in Agar-Slant Tissue Culture: N. Takemori and M. Kitaoka . 710 On the Presence of the Triphosphothiamine (TPT) in the Liver: A. Rossi-Fanelli, N. Siliprandi, and P. Fasella . _.711 Comments and Communications Ernest G. Beinhart, H. A. Cole, and Ben Stern .............. 713 Operations Diagnos...