In this study, a novel interpenetrating polymer network (IPN) hydrogel composed of crosslinked sodium alginate and poly(acryl acid) was prepared for transdermal delivery of an antihypertensive drug, prazosin hydrochloride. Due to the reversible swelling behavior of the hydrogels, the synthesized networks can sense the environmental pH change and achieve an oscillatory release pattern. Using dru...

The aim of the research work was to chemically modify guargum (GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-po...

OBJECTIVE To assess the influence of variable factors such as the size of the airway and the CT imaging parameters such as the reconstruction kernel, field-of-view (FOV), and slice thickness on the automatic measurement of airway dimension. MATERIALS AND METHODS An airway phantom was fabricated that contained eleven poly-acryl tubes of various lumen diameters and wall thicknesses. The measure...

In the present work, a novel interpenetrating polymer network (IPN) hydrogel composed of crosslinked chitosan and poly(acryl acid) was prepared by crosslinking using glutaraldehyde. The model drug, cis-platin, was loaded into the resulted IPN hydrogel. Water absorption of the hydrogel could be switched on and off swiftly by control of pH of the surrounding environment. Therefore, the synthesize...

*Correspondence: Hatsuo Ishida, Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USA e-mail: [email protected] High-performance thermosets via amide–imide functional benzoxazine resins as precursors have been synthesized.The structures of synthesized monomers have been confirmed by 1H NMR and Fourier transform infrared. Among these two benz...

Low density composites of sodium montmorillonite and poly(amide-imide) polymers have been created using an ice templating method, which serves as an alternative to the often-difficult foaming of high temperature/high performance polymers. The starting polymer was received in the poly(amic acid) form which can be cured using heat, into a water insoluble amide-imide copolymer. The resulting mater...

In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. ...