نتایج جستجو برای: polygenic dyslipidemia
تعداد نتایج: 16254 فیلتر نتایج به سال:
Polygenic diseases are caused by the joint contribution of a number of independently acting or interacting polymorphic genes; the individual contribution of each gene may be small or even unnoticeable. The carriage of certain combinations of genes can determine the occurrence of clinically heterogeneous forms of the disease and treatment efficacy. This review describes the approaches used in a ...
conclusions dyslipidemia is a common finding after kidney transplantation and has no correlation with csa level. according to conflicting data on the precise effect of different factors in inducing dyslipidemia, prospective large sample size studies should consider better control of dyslipidemia. results mean age of 1391studied population was 38.7 ± 15 years old. hypercholesterolemia and hypert...
data regarding the effects of dietary protein on modifying serum lipid and lipoprotein levels are controversial. in this study we have investigated the hypothesis whether dietary protein and protein to carbohydrate ratio could be related to subsequent changes in lipid profile in adults.this 3-yaers follow-up_longitudinal study was conducted on a sample of participants (845 men and 1043 women, a...
I study the dynamics of a simple quantitative genetic model describing coevolution of two antagonistic species of the victim-exploiter type. In this model, individuals are different with respect to an additive polygenic character that is under direct stabilizing selection and which also determines the strength of within and between species interactions. The model assumes that between species in...
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association studies (GWAS) on suicide attempt (SA) and ideation have failed to identify specific genetic variants. Here, we conduct further GWAS and for the first time, use polygenic score analysis in cohorts of patients with mood disorders, to test...
Many signals of natural selection have been identified in the human genome. However, except for some single-locus mechanisms, most molecular processes generating these adaptation signals are still unknown. We developed an approach that integrates datasets related to genome-wide association studies (GWAS) with information about systems biology and genetic signatures of natural selection to ident...
A combination of analytical and simulation models is used to explore the initial evolution of genic sex determination from polygenic sex determination. Prior studies have indicated that polygenic sex determination is rare or absent in extant species but that it has likely played an important intermediate role in the evolution of other genetic sex-determination systems. This study explores why p...
Stratification by genetic risk factors for Alzheimer's disease (AD) may help identify groups with the greatest disease risk. Biological changes that cause late-onset AD are likely to occur years, if not decades prior to diagnosis. Here, we select a subset of the Generation Scotland: Scottish Family Health Study cohort in a likely preclinical age-range of 60-70 years (subset n = 3,495 with cogni...
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