Polymeric nanoparticles have received great attention as potential controlled drug delivery systems. Biodegradable polymers has been extensively used in the development of these drug carriers, and the polyesters such as polylactic acid, polyglycolic acid and their copolymers as poly-lactide-co-glycolide are the most used, considering its biocompatibility and biodegradability. Thermal analysis t...

objective(s): the current study reports the production and biocompatibility evaluation of a ternary nanocomposite consisting of ha, pla, and gelatin for biomedical application.materials and methods: hydroxyapatite nanopowder (ha: ca10(po4)6(oh)2) was produced by burning the bovine cortical bone within the temperature range of 350-450 oc followed by heating in an oven at 800. synthesis of the te...

The pursuit for targeted drug delivery systems has led to the development of highly improved biomaterials with enhanced biocompatibility and biodegradability properties. Microand nanoscale components of hydrogels prepared from both natural and artificial components have been gaining significant importance due to their potential uses in cell based therapies, tissue engineering, liquid micro-lens...

In this study, a new type of amphiphilic cetylated polyethyleneimine (PEI) was synthesized, and then polylactic-co-glycolic acid (PLGA)/cetylated PEI/hyaluronic acid nanoparticles (PCPH NPs) were developed by self-assembly as a novel type of gene-delivering vehicle. The PCPH NPs showed good DNA-condensation ability by forming polyplexes with small particle size and positive zeta potential. The ...

Most of the existing fabrication techniques for tissue engineering scaffolds require the use of organic solvents that may never be fully removed even after long leaching hours. The residues of these organic solvents reduce the ability of biological cells to form new tissue. This paper presents an approach toward solvent-free fabrication of tissue engineering scaffolds. Interconnected porous str...

In this paper, we investigate essential mechanical properties and cell behaviors of the scaffolds fabricated by rolling polylactic-co-glycolic acid (PLGA) electrospinning (ES) films for small-diameter vascular grafts (inner diameter < 6 mm). The newly developed strategy can be used to fabricate small diameter vascular grafts with or without pre-seeded cells, which are two main branches for smal...

Abbreviations MEMS Microelectromechanical systems NEMS Nano-electromechanical systems PCL Polycaprolactone PET Polyethylene terephthalate PGA Polyglycolic acid PLA Polylactic acid PU Polyurethane PTFE Poly(tetrafl uoroethylene) PMMA Polymethylmethacrylate UHMWPE Ultrahigh molecular weight polyethylene

Numerous studies have shown that the physicochemical properties of biomaterials can control cell activity. Cell adhesion, proliferation, differentiation as well as tissue formation in vivo can be tuned by properties such as the porosity, surface micro- and nanoscale topography and chemical composition of biomaterials. This concept is very appealing for tissue engineering since instructive prope...

Thermoplastic starch, polylactic acid glycerol and maleic anhydride (MA) were compounded with natural montmorillonite (MMT) through a twin screw extruder to investigate the effects of different loading of MMT on structure, thermal and absorption behavior of the nanocomposites. X-ray diffraction analysis (XRD) showed that sample with MMT loading 4phr exhibited exfoliated structure while sample t...