ABSTRACT The present study involves preparation and evaluation of floating microspheres with famotidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers acrycoat S100 and chitosan. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respe...

The aim of this study was to prepare and evaluate microspheres containing ibuprofen. Microspheres were prepared by modified quasi-emulsion solvent diffusion method. The influence of formulation factors (drug-polymer ratio, volumes of solvent, polyvinyl alcohol concentration and type of polymer) on the morphology, particle size distribution, drug loading capacity, micromeritical properties and t...

In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...

In this study suitable, smooth, spherical, cross-linked egg albumin microspheres in the size range of 15-40 um loaded with norethisterone were prepared by multiple emulsion (o/w/o) method by the glutarldehyde cross-linking and thermal denaturation technique. Microspheres were prepared by using different drug/polymer ratios. Egg albumin was used as a mucoadhesive polymer in the formulation to in...

The purpose of this research was to formulate and systemically evaluate in vitro and in vivo performances of mucoadhesive amoxicillin microspheres for the potential use in the treatment of gastric and duodenal ulcers, which were associated with Helicobacter pylori. Amoxicillin mucoadhesive microspheres containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier polymer were ...

A simple and versatile method is developed for preparing anisotropic polymer particles by pressing polymer microspheres at elevated temperatures. Polystyrene (PS) microspheres are used to demonstrate this approach. Depending on the mechanical deformation and wetting of the polymers on the substrates, polymer structures with special shapes such as barrel-like or dumbbell-like shapes can be prepa...

Synthetic biodegradable polymers of lactic and glycolic acid have been extensively investigated for sustained drug delivery. Drug release from lactide/glycolide polymers can be either diffusion controlled or matrix erosion controlled. Polymer degradation was dependent on the molecular weight of the polymer and matrix structure of the delivery system. High surface area, lower particle size and l...

The objective of the present study was to prepare and characterize in vitro and in vivo performance of a sustained release microsphere formulation of 4-chlorocurcumin, a novel curcumin analogue. A spray dried technique with ethylcellulose as the polymer was used in the preparation of these microspheres. Microspheres were characterized for drug content, particle size and shape, in vitro drug rel...

objective(s) theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. it is used both as a prophylactic drug and to prevent acute exacerbations of asthma. the aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. materials and me...

The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...