Fibrocartilaginous dysplasia is a variant of fibrous dysplasia showing extensive cartilaginous differentiation (enchondroma-like areas). The amount of cartilage varies from case to case. This has been reported more commonly in polyostotic disease. We present a 19 year old boy who presented with multifocal osteolytic lesions involving right femoral neck and lower end of left fibula. Curettage of...

Fibrous dysplasia; Nasal cavity; Skull base; Endoscopic sinus surgery Abstract Fibrous dysplasia is an uncommon benign tumour in the nasal cavity. Due to adjacent vital soft tissue structures surgery is often the treatment of choice. We report a rare case of polyostotic fibrous dysplasia of the mandible and the ethmoid bone including nasal bony septum with intracranial expansion, and include a ...

Fibrous dysplasia of bone is a skeletal disease due to a specific mutation in the GNAS1 gene with a broad spectrum of clinical presentations ranging from isolated monostotic and polyostotic forms to associations with other extra-skeletal manifestations (McCune-Albright syndrome). The main complications are bone pain, deformities and fractures and sometimes cranial nerve compression and the deve...

Fibrous Dysplasia of bone is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Fibrous Dysplasia is characterized either monostotic or polyostotic, and may occur as a component of McCune Albright Syndrome or the rare Mazabraud Syndrome. Long bones, skull bones and ribs are most commonly affected bones. We present a case of a 18 years old boy ha...

Fibrous dysplasia (FD) is a rare bone disorder caused by mutations of the GNAS gene, which are also identified in malignancies. We explored the potential relationship between breast cancer and fibrous dysplasia in two fibrous dysplasia cohorts from the Netherlands and the United States. Data on fibrous dysplasia and breast cancer diagnosis were retrieved from hospital records of 134 (Netherland...

Fibrous dysplasia is a benign fibroosseous bone dysplasia that can involve single (monostotic) or multiple (polyostotic) bones. Monostotic form is more frequent in the jaws. It is termed as craniofacial fibrous dysplasia, when it involves, though rarely, adjacent craniofacial bones. A 16-year-old girl consulted for a painless swelling in the right posterior mandible for two years. Panoramic rad...

Many studies have been made in the past in an effort to understand the pathogenetic factors that are involved in the development of fibrous dysplasia and McCune-Albright syndrome. Recently, with the aid of cellular and molecular biology, the implication of G protein mutations have been demonstrated to be a crucial etiopathogenetic factor for the manifestations of these disorders. In this paper,...