نتایج جستجو برای: polyphenols

تعداد نتایج: 10827  

2016
Chong Zhao Takenori Sakaguchi Kosuke Fujita Hideyuki Ito Norihisa Nishida Akifumi Nagatomo Yukimasa Tanaka-Azuma Yoshinori Katakura

Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-au...

2010
Massimo D’Archivio Carmelina Filesi Rosaria Varì Beatrice Scazzocchio Roberta Masella

The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic co...

Journal: :Journal of the Academy of Nutrition and Dietetics 2012
Martin de Bock José G B Derraik Wayne S Cutfield

T HE GLOBAL PANDEMIC OF TYPE 2 DIABETES mellitus places an incalculable burden on health care systems. In the United States alone, it is estimated that 52% of the population will have diabetes or prediabetes by 2020, conditions that already cost that country $194 billion a year in health care spending. Amelioration of type 2 diabetes mellitus risk usually targets lifestyle and diet, primarily w...

2017
Marta Guasch-Ferré Jordi Merino Qi Sun Montse Fitó Jordi Salas-Salvadó

Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as promoting the uptake of glucose in tissues, and therefore improving insulin sensitivity. This review aims to summarize the evidence from clinical trials and observational prosp...

2018
Monika Gorzynik-Debicka Paulina Przychodzen Francesco Cappello Alicja Kuban-Jankowska Antonella Marino Gammazza Narcyz Knap Michal Wozniak Magdalena Gorska-Ponikowska

Beneficial effects of natural plant polyphenols on the human body have been evaluated in a number of scientific research projects. Bioactive polyphenols are natural compounds of various chemical structures. Their sources are mostly fruits, vegetables, nuts and seeds, roots, bark, leaves of different plants, herbs, whole grain products, processed foods (dark chocolate), as well as tea, coffee, a...

2010
K. S. Shivashankara S. N. Acharya

Epidemiological studies indicate that the higher intake of fruits and vegetables may reduce the risks of many degenrative diseases like cancer, cardiovascular disease, cataract etc. This is attributed mainly to the intake of dietary polyphenols as seen in Mediterranean diets. However, the bioavailability of polyphenols is reported to be low due to poor absorption in the gut, intestine and colon...

2018
Md Nur Alam Muhammad Almoyad Fazlul Huq

Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the third among males. The objective of this review is to describe the activity of a variety of polypheno...

2016
Chantal Julia Mathilde Touvier Camille Lassale Léopold Fezeu Pilar Galan Serge Hercberg Emmanuelle Kesse-Guyot

Polyphenols have been suggested as protective factors for a range of chronic diseases. However, studying the impact of individual polyphenols on health is hindered by the intrinsic inter-correlations among polyphenols. Alternatively, studying foods rich in specific polyphenols fails to grasp the ubiquity of these components. Studying overall dietary patterns would allow for a more comprehensive...

2015
Luyun Cai Shucheng Liu Lijun Sun Yaling Wang Hongwu Ji Jianrong Li

Tea polyphenols (TP) have shown antioxidant activity and antimicrobial properties in the food industry. Assessment of anti-oxidation potential of 6-gingerol (GR) has also been verified. As little is known about the use of tea polyphenols either individually or in combination with 6-gingerol in shrimp paste, we aimed to investigate the effect of tea polyphenols combined with 6-gingerol on the bi...

Journal: :The Journal of biological chemistry 2008
Xiuyun Hou Shanqin Xu Karlene A Maitland-Toolan Kaori Sato Bingbing Jiang Yasuo Ido Fan Lan Kenneth Walsh Michel Wierzbicki Tony J Verbeuren Richard A Cohen Mengwei Zang

Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of AMPK signaling and hepatocellular lipid met...

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