Aurora kinases are overexpressed in large numbers of tumors and considered as potential therapeutic targets. In this study, we found that the Aurora kinases inhibitors MK-0457 (MK) and ZM447439 (ZM) induced polyploidization in acute myeloid leukemia (AML) cell lines. The level of glycolytic metabolism was significantly increased in the polyploidy cells, which were sensitive to glycolysis inhibi...

Chromosome evolution in flowering plants is often punctuated by polyploidy, genome duplication events that fundamentally alter DNA content, chromosome number, and gene dosage. Polyploidy confers postzygotic reproductive isolation and is thought to drive ecological divergence and range expansion. The adaptive value of polyploidy, however, remains uncertain; ecologists have traditionally relied o...

Whole-genome duplication (WGD), or polyploidy, is a major force in plant genome evolution. A duplicate of all genes is present in the genome immediately following a WGD event. However, the evolutionary mechanisms responsible for the loss of, or retention and subsequent functional divergence of polyploidy-derived duplicates remain largely unknown. In this study we reconstructed the evolutionary ...

Rationale: Polyploidy and multinucleation are characteristic features of mammalian cardiomyocytes, which develop shortly after birth when most differentiated cardiomyocytes become acytokinetic. Cardiac overload and hypertrophy further increase the degree of polyploidy of cardiomyocytes, suggesting a role in cell type–specific responses to physiological and pathological stimuli. Objective: We so...

Effect of Colchicine on Polyploidy Induction and Morphophysiological Characteristics Ajowan (Carum copticum L.) Population Sistan Geographical Area

the present study reports the chromosome number and meiotic behaviour of 14 populationsbelonging to four taxa of anchusa subgenus buglossum gusul. from iran. all populationsshowed the chromosome number 2n= 4x= 32. it is the first meiotic study for a. subg.buglossum. we discuss some habit form and evolutionary aspect in the light of cytogeneticdata. the origin of polyploidy (auto-allopolyploidy)...

We report a case of chronic lymphocytic leukemia with a characteristic cytogenetics finding detected by fluorescent in situ hybridization. This case has deletion in p53 gene in 50% of interphase nuclei studied in the peripheral blood and polyploidy in 30% of cells. To our knowledge polyploidy is not commonly reported with chronic lymphocytic leukemia patients.

Polyploidy induction in German chamomile (Matricaria chamomilla L.) by herbicide trifluralin   Leila Karami1, Mohammad Modarresi2, Mohammad Amin Kohanmoo2, Fatemeh Zahabi Ahmadi2 & Saeed Irian3 1Department of Horticulture, Faculty of Agriculture and Natural Resources, Persian Gulf University, Bushehr, 7516913817, Iran; 2Department of Plant Breeding, Faculty of Agriculture and Natural Resourc...