BACKGROUND AND PURPOSE As part of the recruitment efforts for the National Institutes of Health Tissue Plasminogen Activator Pilot Study, public education and awareness campaigns were conducted to encourage early hospital arrival. We evaluated the change in arrival times during the course of the study for all stroke patients, including those who were not entered into study. METHODS Data were ...

Some strains of West Nile virus (WNV) are neuroinvasive and may induce fatal encephalitis/meningitis in a variety of animal species including humans. Whether, however, there is a strain-specific signature in the brain is as yet unknown. Here we investigated the neuropathogenesis induced by two phylogenetically distant WNV strains of lineage 1, WNV(IS98) and WNV(KUN35 911). While four-week old C...

OBJECTIVE Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this study was to characterise the peripheral mechanisms contributing to the analgesic effects of anti-NGF antibody treatment in an established model of jo...

Patient Population The program serves people who frequently call 911 in situations not considered to be an emergency, patients who call 911 with low-acuity medical complaints, patients at risk for potentially preventable admissions or readmissions, and patients at risk for hospice status revocation (updated January 2013).Vulnerable Populations > Medically uninsured; Insurance Status > Uninsured...

The I1 subtype of imidazoline receptors (I1R) is a plasma membrane protein that is involved in diverse physiological functions. Available radioligands used so far to characterize the I1R were able to bind with similar affinities to 2-adrenergic receptors ( 2-ARs) and to I1R. This feature was a major drawback for an adequate characterization of this receptor subtype. New imidazoline analogs were...

BACKGROUND AND PURPOSE Improving actionable stroke knowledge of a witness or bystander, which in some cases are children, may improve response to an acute stroke event. METHODS We used a quasiexperimental pre-test post-test design to evaluate actionable stroke knowledge of 210 children aged 9 to 10 years in response to a single, 15-minute exposure to a stroke education video game conducted in...

Let A be a Tychonoff space. As is well known, the points of the Stone-Cech compactification ßX "are" the zero-set ultrafilters of X, and the points of the Hewitt real-compactification vX are the zero-set ultrafilters which are closed under countable intersection. It is shown here that a zeroset ultrafilter is a point of the Dieudonné topological completion SX iff the family of complementary coz...