Abstract Extra temporal lobe epilepsy (eTLE) may involve heterogenous widespread cerebral networks. We investigated the structural network of an eTLE cohort, at postulated epileptogenic zone later surgically removed, as a node; resection (RZ). hypothesised patients with abnormal connection to/from RZ, to have proportionally increased abnormalities based on topological proximity in addition poor...

One challenge in modern medicine is to control epilepsies that do not respond to currently available medications. Since seizures consist of coordinated and high-frequency neural activity, our goal was to disrupt neurotransmission with a synaptic transmission mutant and evaluate its ability to suppress seizures. We found that the mutant shibire, encoding dynamin, suppresses seizure-like activity...

Introduction: Post-traumatic seizures can occur as a complication of head injury, whether it is immediately after the injury to months or years after. Phenytoin an anti-epileptic drug that has been used widely prophylaxis for posttraumatic seizures. Method: The study was conducted retrospectively using medical records trauma patients in hospitals 2020-2022 on 54 samples treated up seven days po...

BACKGROUND Stroke is the second most common cause of seizures in term neonates and is associated with abnormal long-term neurodevelopmental outcome in some cases. OBJECTIVE To aid diagnosis earlier in the postnatal period, our aim was to describe the characteristic EEG patterns in term neonates with perinatal arterial ischaemic stroke (PAIS) seizures. DESIGN Retrospective observational stud...

PURPOSE To determine the effects of high-frequency electrical stimulation on electrographic seizure activity during and after stimulation (ON-effect and OFF-effect). METHODS The modulation and suppression of epileptiform activity during (ON-effect) and after (OFF-effect) high-frequency electrical stimulation was investigated using the high-K(+) and picrotoxin hippocampal slice epilepsy models...

PURPOSE This study investigates the efficacy of transylvian selective amygdalohippocampectomy (TS SAH) in children with medically intractable epilepsy due to unilateral hippocampal sclerosis. Post-surgical seizure control, intellectual and memory outcomes are examined. METHOD This study reports on pre- and post-surgical clinical data from 10 patients who underwent TS SAH between 2002 and 2010...

OBJECTIVE Phenobarbital increases electroclinical uncoupling and our preliminary observations suggest it may also affect electrographic seizure morphology. This may alter the performance of a novel seizure detection algorithm (SDA) developed by our group. The objectives of this study were to compare the morphology of seizures before and after phenobarbital administration in neonates and to dete...

Acute hyperammonemic encephalopathy is generally associated with severe liver disease, manifesting neuropsychiatric symptoms including confusion, lethargy, seizure, coma, and even death. Electroencephalogram (EEG) a proven diagnostic, prognostic, therapeutic tool in patients acute chronic encephalopathies. EEG changes are background slowing theta to delta ranges, accompanied by presence of trip...

Vagal nerve stimulation using an NCP (Cyberonics) device has been suggested as a potential treatment for patients with epilepsy that has previously proven refractory. Ten patients in Northern Ireland have had this device implanted and been fully audited pre- and post-operatively. Twelve months post-implantation, five patients have demonstrated a greater than 50% reduction in seizure frequency. ...