Giant retinal tear (GRT) is defined as peripheral break extending through 900 or more of the retinal circumference in which the vitreous gel is attached essentially to the anterior flap thereby allowing independent mobility of the posterior edge of tear. GRT needs to be differentiated from Giant dialysis, which is retinal disinsertion from the ora serrata with 90 degrees or more of circumferent...

PURPOSE To investigate the clearance of vascular endothelial growth factor (VEGF) after the induction of posterior vitreous detachment by plasmin and/or SF(6). METHODS The study design included four groups of rabbits: group 1 received an intravitreal injection of plasmin and SF(6) in the right eye, group 2 received an intravitreal injection of plasmin in the right eye, group 3 received an int...

PURPOSE To determine whether aging vitreous collagen fibrils undergo ultrastructural changes that might underlie vitreous liquefaction and posterior vitreous detachment. METHODS Vitreous collagen fibrils from 21 human subjects (age range, 3-89 years) and from bovine eyes were isolated on electron microscopy grids. Cupromeronic blue labeling in the presence of 0.3 M MgCl(2) and immunogold labe...

Most retinal detachments are preceded by a posterior vitreous detachment (PVD), which causes traction on the retina and, potentially, a retinal tear. The liquefied vitreous can then seep under the retina, causing it to detach. Retinal detachments may initially be localised, but without treatment they may progress and lead to irreversible vision loss. Early recognition and prompt referral are th...

PURPOSE To assess optical coherence tomography (OCT) for diagnosing posterior vitreous detachment (PVD) at the macular region compared to kinetic B-scan ultrasonography. METHODS In the present study, the authors prospectively investigated the frequency of PVD at the posterior pole utilizing ocular kinetic B-mode sonography in 315 eyes of 188 patients (113 female, 75 male; mean age, 72.8 years...