Renalase, a recently discovered enzyme released by the kidneys, breaks down blood-borne catecholamines and may thus regulate blood pressure (BP). Animal studies have suggested that high levels of dietary salt might reduce blood and kidney renalase levels. We conducted a randomized trial to assess the effects of altered salt and potassium intake on serum renalase levels and the relationship betw...

Hypokalaemia is a common clinical problem. It can lead to severe disturbances in cardiac, neurological and muscle function. We present the case of a 45-year-old woman who was transported to our hospital with cardiac arrest following ventricular fibrillation. Blood sampling revealed severe acidosis (pH 7.02) and extreme hypokalaemia (0.9 mmol/l). The low serum potassium level was most likely cau...

UNLABELLED As the renal function progressive decline is often correlated to diuresis impairment, potassium level changes represent a major pathophysiological factor in monitoring chronic kidney disease. Even more, potassium level imbalance could lead to life-threatening situations with the risk of severe rhythm disorders appearance. The aim of the study was to determine in which degree the seru...

Darrow and his associates (1, 2) have recently obtained evidence that a correlation exists between the concentration of serum bicarbonate, muscle potassium, and intracellular sodium from a study on rats subjected to procedures designed to produce a deficit of one of the ions sodium, chloride, or potassium. Thus, the serum bicarbonate concentration was found to vary directly with the intracellul...

BACKGROUND Sodium polystyrene sulfonate (SPS) is a potassium-binding resin that is commonly used to treat mild hyperkalemia. However, there is limited evidence supporting its effectiveness in the short-term management of hyperkalemia. OBJECTIVE To determine whether SPS is effective in reducing serum potassium in general medical patients after a single oral dose. METHODS A retrospective obse...

OBJECTIVE To compare different strategies predicting hyperkalemia (serum potassium level ≥5.5 mEq/l) in hospitalized patients for whom medications triggering potassium-increasing drug-drug interactions (DDIs) were ordered. MATERIALS AND METHODS We investigated 5 strategies that combined prediction triggered at onset of DDI versus continuous monitoring and taking into account an increasing num...

IMPORTANCE Hyperkalemia is a potentially life-threatening condition predominantly seen in patients treated with renin-angiotensin-aldosterone system (RAAS) inhibitors with stage 3 or greater chronic kidney disease (CKD) who may also have diabetes, heart failure, or both. OBJECTIVES To select starting doses for a phase 3 study and to evaluate the long-term safety and efficacy of a potassium-bi...

normotensive hyperaldosteronism is a rare disorder. it is usually diagnosed with hypokalemia or an adrenal mass. our patient was a 27-year-old female presented with weakness. she had normal blood pressure, hypokalemia, high plasma aldosterone level and suppressed plasma renin activity. after the saline load, test aldosterone didn’t show suppression. adrenal computed tomography revealed a left a...

Background: Heart failure is one of the common cardiovascular diseases and digoxin has the positive effect on it. But unfortunately in spite of its positive effect on heart failure therapeutic and toxic level of it in patients is different and close to each other. The aim of this research was determination of digoxin serum level in failur heart patients. Materials and methods: In this cros...

Potassium oxonate, a selectively competitive uricase inhibitor, produced hyperuricemia (HUA) in rodents in a previous study. In this study, we employed the tree shrew as an animal model to study potassium oxonate-induced HUA. The effect of allopurinol (ALLO), a uric acid reducer, was also examined in this model. Potassium oxonate at doses of 5, 20, 40, 60, 80, 100, and 1,000 mg/kg was given int...