OBJECTIVE: To compare the value and effectiveness of different prioritization strategies of pre-exposure prophylaxis (PrEP) in New York City (NYC). DESIGN: Mathematical modelling utilized as clinical trial is not feasible. METHODS: Using a model accounting for both sexual and parenteral transmission of HIV, we compare different prioritization strategies (PPS) for PrEP with two scenarios - n...

The acute respiratory distress syndrome (ARDS) is a severe alteration in lung structure and function that develops secondary to a traumatic stimulus. When ARDS develops following cardiopulmonary bypass (CPB) it is know as postpump syndrome (PPS). ARDS can be caused by a single massive insult ("hit"); however, sequential minor insults ("hits") are more common clinically. The concept of multiple ...

This study describes the significant correlation between the Braden Scale (BS) and the Palliative Performance Scale (PPS) in patients with advanced illness that has not been previously reported. The analysis was based on a prospective sequential case series of 664 patients suffering from advanced illness who were referred to a regional palliative medicine programme in Toronto, Canada. Baseline ...

Drought limits crop productivity and reduces yield stability. tolerance as a selection criterion in breeding programs requires the development of high-throughput, precise, low-cost phenotyping strategies. We developed mathematical model, based on biological approaches, for evaluating soybean plants’ response to drought under controlled growth conditions. The model describes kinetics water consu...

Most patients with tyrosine kinase inhibitor (TKI)-sensitive non-small cell lung cancer (NSCLC) eventually develop acquired resistance to TKIs. Factors that affect TKI-sensitive patient survival after progression during TKI treatment remain unknown. We attempted to identify factors that affected post-progression survival. We retrospectively reviewed 81 advanced NSCLC patients with disease progr...

As Grids are loosely-coupled congregations of geographically distributed heterogeneous resources, the efficient utilization of the resources requires the support of a sound Performance Prediction System (PPS). The performance prediction of grid resources is helpful for both Resource Management Systems and grid users to make optimized resource usage decisions. There have been many PPS projects t...

The workload of a computer system is traditionally de ned as all inputs from the user to the system As the use of this real workload is usually impossible in most performance analysis studies it is necessary to abstract from the real workload and to construct a test workload model There are already quite established methodologies and techniques for workload modeling of uniprocessor systems but ...

The immune system of the newborn is immature, and therefore it is difficult to induce protective immunity by vaccination in the neonatal period. Immunization of mothers during pregnancy against infections caused by encapsulated bacteria could thus be particularly attractive, as infants do not respond to polysaccharide (PS) antigens. Transmission of maternal vaccine-specific antibodies and prote...

The diagnostic issues, classification, incidence, genetic factors, and theories of etiology of psychiatric illness associated with childbirth are reviewed. Psychologic influences, psychosocial factors and the concept of biologic maladaptation associated with prospective motherhood are discussed. Postpartum mental distress is not a unitary phenomenon. The physiology of the puerperium is thus not...

GQM+Strategies is an approach that aligns the business goals at each level of an organization to strategies to achieve overall business goals and assesses the achievement of such goals. Strategies are extracted from business goals based on rationales (contexts and assumptions). Using the proposed approach, which refines the GQM+Strategies model by extracting rationales based on the analysis of ...