..................................................................................................................... iv INTRODUCTION .............................................................................................................1 CHAPTER 1: DEVELOPMENT .....................................................................................5 CHAPTER 2: PRE-PRODUCTION....................

The aim of this study was to investigate role of the N-Methyl-D-Aspartate (NMDA) receptors in the decrease of morphine analgesia in mice after nociceptive sensitization. We used a hot plate test to assess effects of morphine on pain behavior in male NMRI mice. All drugs were administered through an intraperitoneal route. Sensitization schedule composed of 3-days pre-treatment of morphine (20mg/...

F. WHO Review History: Dronabinol was included in Schedule I of the 1971 Convention on Psychotropic Substances at the time of its adoption as Delta-9tetrahydrocannabinol together with several other isomers of tetrahydrocannabinol. At its 26 meeting, ECDD recommended that dronabinol, which is the (-)-trans isomer of delta-9-tetrahydrocannabinol, be moved to Schedule II, while keeping the other s...

Background 5-HT1B receptor agonists enhance cocaine intake during daily self-administration sessions but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1B receptor agonists produce similar abstinence-dependent effects on methamphetamine intake. Methods Male rats were trained to self-administer methamphetamine (0.1 mg/kg, i.v.) on low (fixed ratio 5 and vari...

Pneumococcal conjugate vaccines (PCVs) have substantially reduced morbidity and mortality of pneumococcal disease. The impact of the 7-valent PCV on all-serotype invasive pneumococcal disease (IPD) among children was reported to vary between high-income countries. We investigate the ability to predict this heterogeneity from pre-vaccination data. We propose a parsimonious model that predicts th...

a project is any endeavor involving planned action, for example, developing a new product or constructing a dam. [ce1] major factors for a project to be successful are applying performance measurement and feedback tool. one such well-known performance measurement tool to control the project execution is earned value management (evm). evm uses the fundamental principle that trends in the past ca...

In this paper a 0–1 linear programming model and a solution heuristic algorithm are developed in order to solve the so-called Master Surgical Schedule Problem (MSSP). Given a hospital department made up of different surgical units (i.e. wards) sharing a given number of Operating Rooms (ORs), the problem herein addressed is determining the assignment among wards and ORs during a given planning h...

Timetables of mass transportation systems contain an information not only about the traffic flows in the network, but also about the topology of the physical infrastructure of the network. However, this data is not given explicitly; it requires an nontrivial preprocessing to be revealed. We propose an algorithm that extracts the physical structure and the network of traffic flows from timetable...