Oral Submucous fibrosis (OSMF) is a well-known debilitating precancerous condition of oral cavity which results due to chewing tobacco, areca nuts and its related products. It is an irreversible condition with very high malignant potential. There is a dire need to curb this common but avoidable condition that is increasingly observed in the younger age groups which leads to early development of...

Precancerous skin lesions are associated with high probability of malignant transformation to squamous cell carcinoma. Early detection and management necessary improve prognosis outcomes. Literatures showed that topical photodynamic therapy (PDT) is a promising treatment method which can be successfully applied in several conditions dermatology. This study aims review the efficacy PDT for vario...

OBJECTIVE We attempted to reveal the changes of the human telomerase reverse transcriptase (hTERT) alternative splicing pattern in gastric carcinogenesis. METHODS Three alternative splicing sites (alpha, beta, gamma) were selected and designed PCR primer. The expression of 8 hTERT alternative splicing variants (ASVs) in normal gastric mucosa, precancerous lesions and gastric cancer were detec...

BACKGROUND Previous studies found that topical photodynamic therapy (PDT) is very effective for human oral precancerous lesions. METHODS This study evaluated whether topical photosan-mediated PDT (topical photosan-PDT), using a 640-nm light-emitting diode (LED) light, is an effective treatment modality for hamster buccal pouch precancerous lesions. Fourteen 7,12-dimethylbenz(a)anthracene (DMB...

For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy a...

INTRODUCTION The magnitude of precancerous cervical cancer lesions as well as invasive cervical cancer is higher in HIV-infected women than non HIV-infected women. Thus, screening targeting HIV-infected women is being undertaken in developing countries, including Ethiopia. However, data on the prevalence and determinants of precancerous cervical cancer lesion among HIV-infected women in souther...

Plummer-Vinson syndrome (PVS) is the triad of iron-deficiency anemia, esophageal webs and dysphagia. This article discusses first reported case PVS from Oman. A female patient in her 40s presented with a one-year history dysphagia odynophagia known background untreated anemia. After an elaborate workup, diagnosis was made following visualization web barium swallow study esophagogastroduodenosco...

Oral submucous fibrosis (OSMF), a precancerous condition of the oral cavity, has been studied by a number of workers in the field. The available epidemiological data showed a clear-cut geographical and ethnic predisposition, which suggested that certain customs/habits prevalent among the population groups in south-east Asia might be possible etiological factors. However, none of these customs w...

Oral submucous fibrosis (OSMF) is a collagen disorder commonly seen in the Indian subcontinent ,it is a complex precancerous condition. It was initially found mainly in India but it is now often seen in the Asian populations belonging to United Kingdom, USA, and other developed countries, and is therefore a serious concert for global health, causative agent of osmf is considered to be areca-nut...

Objective: This study aims to investigate the clinical significance of gastrin 17 and pepsinogen in gastric cancer and precancerous lesion screening. Methods: We used ELISA to measure the levels of gastrin 17 and pepsinogen in serum from the medical examination population, which compared to endoscopic results. Then statistical analysis was performed. Results: The classical method by testing pep...