There is ample evidence to suggest that the paraventricular nucleus of the thalamus (PVT) mediates cue-reward learning, especially as it relates to drug-seeking behavior. However, its exact role in these complex processes remains unknown. Here we will present and discuss data from our own laboratory which suggests that the PVT plays a role in multiple forms of stimulus-reward learning, and does...

Abstract Chronic exposure to methamphetamine (METH) causes severe and persistent cognitive impairment. The present study aimed investigate the role of dynorphin/κ opioid receptor (KOR) system in development METH‐induced We found that mice showed significant impairment novel object recognition test (NOR) following daily injections METH (10 mg/kg) for seven consecutive days. Systemic blockade KOR...

An emerging view of prefrontal cortex (PFC) function is that multiple PFC areas process information in parallel, rather than as distinct modules. Two key functions assigned to the PFC are the regulation of top-down attention and stimulus-guided action. Electrophysiology and lesion studies indicate the involvement of both the anterior cingulate cortex (ACC) and prelimbic cortex (PL) in these fun...

It has been found that the medial prefrontal cortex (mPFC) is involved in memory encoding of aversive events, such as inhibitory avoidance (IA) training. Dissociable roles have been described for different mPFC subregions regarding various memory processes, wherein the anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL) are involved in acquisition, retrieval, and...

Abbreviations: ECBS, Endocannabinoids; AEA, An amide hydrolase; CB1, Cannabinoid type 1 receptor; CB2 TRPV1, Transient potential vanilloid type 1 receptor; CBD, tex; MPFC, Medial prefrontal córtex; PL, Prelimbic; HI Hippocampus; PAG, Periaqueductal gray matter; THC, Δ9 Elevated plusmaze; VCT, Vogel conflict test; AP, Anteropos ⁎ Corresponding author at: Pharmacology Departme Preto, University o...