OBJECTIVE Methylxanthines and doxapram are currently used to treat apnea of prematurity but are not fully effective and often present undesirable side effects. The present study examines whether exposure to an odor known to modulate the infant's respiratory rate could reduce the frequency of apneic spells. METHOD Fourteen preterm newborns born at 24 to 28 gestational weeks presenting recurren...

Occurrence of the premature birth in Ukraine is about 6%. Premature newborns are highest risk group developing chronic pathology nervous system, sensory organs, and respiratory causing neonatal mortality disability; latter 22 times higher than full-term ones. Besides, there a large rare metabolic disorders that significantly disrupt adaptation nursing with signs morpho-functional enzymes immatu...

OBJECTIVES To determine the rate of magnetic resonance imaging (MRI)-detected noncystic white matter injury (WMI) in a prospective cohort of premature newborns, and to evaluate its associations with changes in clinical predictors of WMI over the study period. STUDY DESIGN A prospective cohort of premature newborns (<33 weeks gestational age) was studied with MRI within 4 weeks of birth and ne...

Administration of probiotics to premature newborns has been shown to prevent necrotizing enterocolitis and reduce all-cause mortality. In our hospital, we documented 2 cases of Bifidobacterium longum subspecies infantis bacteremia in newborns receiving probiotics. By comparative genomics, we confirmed that the strains isolated from each patient originated from the probiotics.

BACKGROUND Bacterial sepsis is a major threat in neonates born prematurely, and is associated with elevated morbidity and mortality. Little is known on the innate immune response to bacteria among extremely premature infants. METHODOLOGY/PRINCIPAL FINDINGS We compared innate immune functions to bacteria commonly causing sepsis in 21 infants of less than 28 wks of gestational age, 24 infants b...

OBJECTIVE To evaluate the impact of music therapy on breastfeeding rates among mothers of premature newborns. METHOD In this open randomized controlled trial, mothers of premature neonates weighting ≤ 1,750 g were submitted to music therapy sessions three times a week for 60 minutes. The endpoints were breastfeeding rates at the moment of infant hospital discharge and at follow-up visits (7-1...