Retinopathies are a group of monogenetic or complex retinal diseases associated with high unmet medical need. Monogenic disorders are caused by rare genetic variation and usually arise early in life. Other diseases, such as age-related macular degeneration (AMD), develop late in life and are considered to be of complex origin as they develop from a combination of genetic, ageing, environmental ...

Introduction: The prevalence of retinopathy of prematurity is expected to increase along with the developing of premature infants’ care and better prognosis of these infants. The aim of this study was to evaluate the prevalence of retinopathy of prematurity in preterm infants. Methods: According to this cross-sectional study, one same ophthalmologist examined the eyes of all the babies at 4 we...

PURPOSE To characterize the genomic organization of human IMPG2, the gene encoding the retinal interphotoreceptor matrix (IPM) proteoglycan IPM 200, to evaluate its relationship to IPM 150, and to evaluate its involvement in inherited retinopathies, such as age-related macular degeneration, retinitis pigmentosa, and Leber congenital amaurosis. METHODS After isolation of human genomic clones, ...

Retinopathic changes are common to many ocular diseases and if detected early, much of the change caused by various injuries can be prevented or in some cases reversed. However, detection and quantification of these changes currently requires tedious invasive and manual examination of retinal wholemount images. To remedy the quantitative limitations, we have designed a software system to automa...

background and purpose: prematurity birth occurs when a newborn is born before the thirty seventh week of pregnancy. preterm birth is the most expensive and the most common health problem. so, the aim of this study was to do epidemiological survey of prematurity in gonbad-e kavous in 2010. materials and methods: this sectional- descriptive study was carried out on 172 premature babies with cens...

AIM To determine an aetiological diagnosis in patients presenting with necrotising retinopathies that simulate acute retinal necrosis (ARN). METHODS Retrospective non-comparative case series. The charts of 16 patients presenting with a clinical impression of ARN at Pitie-Salpetriere Hospital, Paris, France, between 1994 and 1999, who required initial antiviral therapy were reviewed. All of th...

OBJECTIVE To report the results of treating autoimmune retinopathy (AIR) with immunosuppression therapy. METHODS Retrospective review of 30 consecutive patients with AIR followed for 3 to 89 months (median, 17 months) who were treated with immunosuppression (systemic or local). Subgroups were cancer-associated retinopathy (CAR), nonparaneoplastic AIR (npAIR), and npAIR with cystoid macular ed...

BACKGROUND Globally, prematurity is the leading cause of death in children under the age of 5. Many efforts have focused on clinical approaches to improve the survival of premature babies. There is a need, however, to explore psychosocial, sociocultural, economic, and other factors as potential mechanisms to reduce the burden of prematurity. Women's empowerment may be a catalyst for moving the ...

introduction: infant mortality index is an important health indicator. this index has a direct impact on infant mortality and mortality of children less than five years. the present study aimed to investigate causes of infant deaths during 2010-2011 in bandar abbas hospital of children. methods: in this cross - sectional retrospective study profiles of all dead newborns who aged from 0 to 28 da...