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background sall gene family represent a group of evolutionary conserved zinc finger transcription factors which are involved in normal development. it includes four members (sall1 to sall4). sall4 has significant roles in the maintenance of pluripotency and self-renewal, efficient proliferation /stabilization and cell fate decision of embryonic stem cells (escs). our aim in this study was to an...
stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...
introduction: chemokine receptors are found on the surface of stem cells. there have been 19 distinct chemokine receptors described in mammals. chemokines are major players in migration and homing. therefore, changes in their levels or function can help us to increase the migratory potential of these cells. valproic acid differs in structure from other drugs in common use. the way in which valp...
refractory celiac disease (rcd) is when malabsorption symptoms and villous atrophy persist despite strict adherence to a gluten free diet (gfd) for more than 12 months and other causes of villous atrophy have been ruled out. rcd is considered a rare disease and almost exclusively occurs in adults. persistent diarrhea, abdominal pain, weight loss are the most common symptoms in rcd. also, anemi...
the diagnosis of functional constipation (fc) is usually straightforward. almost 95% of childhood constipation is functional in nature. the remaining 5% can be attributed to wide variety of conditions. many of these etiologies are obvious by history and examination and many have other specific symptoms besides constipation. it is especially important to look for presence of any symptoms or sign...
childhood constipation is ofton a long_term problem requiring treatment over months or years. there is no single treatment metod for constipation and many children do not respond and continue to have chronic problems. treatment is consisted of: disimpaction,drug adminstration , diet modilation, and behaverial therapy. it is necessary in all cases that not responding to conventional therapy, un ...
introduction: infants born with congenital anomalies demand individualized nutritional evaluations and recommendations. the anatomical changes of neonatal surgical diseases create specific physiological constraints.patients with different congenital anomalies have different nutritional support needs. it is essential to know the exact physiology of these anomalies in order to be able to manage a...
helicobacter pylori is a gram-negative, spiral-shaped, microaerophilic organism that colonizes the stomach of humans and causes chronic-active gastritis, peptic ulcer disease, and gastric cancers, including adenocarcinoma of the stomach and malt (mucosal-associated lymphoid tumor) lymphomas. h. pylori colonizes the stomach of over 50 % the world’s human population, primarily those who reside in...
introduction: patients with cystic fibrosis have increased risk of malnutrition. early detection of nutritional deterioration enables prompt intervention and correction. the aims of this project were to: - define the nutritional status of cf patients in iran and new zealand - compare and contrast the macdonald nutritional screening tool with the australasian guidelines for nutrition in cyst...
background/aims: inflammatory bowel disease (ibd) is a chronic disease of the gastrointestinal tract, whose etiologies are still unknown. this study was performed to evaluate the humoral immune response in terms of b cell functions in selected ibd patients. methods: eighteen pediatric patients with ibd, including 12 cases of ulcerative colitis (uc) and six with crohn disease (cd), were enrolled...
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