Bacterial infections, even without any perinatal risk factors, are common in newborns, especially in preterm neonates. The aim of this study was to evaluate possible impairment of neutrophil chemotaxis in term and preterm neonates compared with adults as well as neonates with different modes of delivery and anaesthesia. We analysed the expression of the adhesion molecule L-Selectin as well as s...

INTRODUCTION The optimization of enteral nutrition is a priority in preterm neonates worldwide. Probiotics are known to improve gut maturity and function in preterm neonates. To our knowledge, previous systematic reviews have not adequately assessed the effects of probiotic supplementation on enteral nutrition in preterm neonates. OBJECTIVE We assessed the evidence on effects of probiotics on...

Serum bile acids (BA) reference values are lacking for neonates. Therefore, this study aimed to determine serum BA reference values in term and preterm neonates. Furthermore, as serum BA concentrations are well-known to rise in septic adults, BA values were determined in early-onset neonatal sepsis (EOS), a common and serious disease in neonates.Using high-performance liquid chromatography-high...

BACKGROUND Maternal smoking during the third trimester reduces the birthweight of the full-term neonate. We assessed the relationship between the timing of exposure to maternal smoking, gestational period, weight and body length for both full-term and preterm neonates. METHODS A retrospective study with a questionnaire was conducted in 1194 infants who participated in the official medical exa...

introduction preterm birth is still a major health problem throughout the world. preterm birth results in 75% of neonatal mortality. we sought to identify risk factors which cause preterm birth. materials and methods this cross-sectional study assessed all preterm neonates born in asali hospital in khorram abad (either by nvd or c/s) during the first 6 months of 2007. sampling method was census...

BACKGROUND Preterm infants are at risk for neurodevelopmental sequelae even in absence of major cerebral lesions. The hypothesis that Human Recombinant Erythropoietin (rEpo) could improve the neurodevelopmental outcome in risk neonates has raised the highest interest in recent years. METHODS A group of preterm neonates born at a gestational age ≤ 30 weeks and free from major cerebral lesions ...

OBJECTIVE To compare the characteristics of neonatal seizures between preterm and full-term infants in intensive care unit. METHOD A prospective study was developed with 104 high-risk newborn, 30 preterm and 74 full-term infants, with clinical seizures. The dependent variable was gestational age. STATISTICAL ANALYSES Fisher's exact test, odds-ratio and Mann Whitney U test. RESULTS There w...

BACKGROUND Bubble continuous positive airway pressure (BCPAP) is a low-cost nasal CPAP delivery system with potential benefits for developing nations. The objective of the study was to compare the efficacy and safety of BCPAP with ventilator CPAP (VCPAP) in preterm neonates with moderate respiratory distress. METHODS In a pilot randomized controlled trial, 30 preterm neonates (gestation <37 w...

Paracetamol is commonly used to control mild-to-moderate pain or to reduce opioid exposure as part of multimodal analgesia, and is the only compound recommended to treat fever in neonates. Paracetamol clearance is lower in neonates than in children and adults. After metabolic conversion, paracetamol is subsequently eliminated by the renal route. The main metabolic conversions are conjugation wi...