Many current-generation human immunodeficiency virus (HIV) vaccines induce specific T cells to control acute viremia, but their utility following infection with escape mutant virus is unclear. We studied reversion to wild type of an escape mutant simian-HIV in major histocompatibility complex-matched vaccinated pigtail macaques. High levels of vaccine-induced CD8+ T cells strongly correlated wi...

On-line portfolio selection has attracted increasing interests in machine learning and AI communities recently. Empirical evidence show that stock’s high and low prices are temporary and stock price relatives are likely to follow the mean reversion phenomenon. While the existing mean reversion strategies are shown to achieve good empirical performance on many real datasets, they often make the ...

BACKGROUND The CPCRA 064 study examined the effect of structured treatment interruption (STI) of up to 4 months followed by salvage treatment in patients failing therapy with multi-drug resistant HIV. We examined the relationship between the reversion rate of major reverse transcriptase (RT) resistance-associated mutations and change in viral replication capacity (RC). The dataset included 90 p...

an artificial neural network (ann) model is developed for the analysis, simulation, and prediction of the austenite reversion in the thermo-mechanical treatment of 304l austenitic stainless steel. the results of the ann model are in good agreement with the experimental data. the model is used to predict an appropriate annealing condition for austenite reversion through the martensite to austeni...

CD8+ cytotoxic T lymphocytes (CTL) can be effective at controlling HIV-1 in humans and SIV in macaques, but their utility is partly offset by mutational escape. The kinetics of CTL escape and reversion of escape mutant viruses upon transmission to MHC-mismatched hosts can help us understand CTL-mediated viral control and the fitness cost extracted by immune escape mutation. Traditional methods ...

An artificial neural network (ANN) model is developed for the analysis, simulation, and prediction of the austenite reversion in the thermo-mechanical treatment of 304L austenitic stainless steel. The results of the ANN model are in good agreement with the experimental data. The model is used to predict an appropriate annealing condition for austenite reversion through the martensite to austeni...

Reversion of L forms to the normal bacterial state has been described in general terms in a variety of bacterial cell-L-form systems (Dienes and Weinberger, 1951). The relatively large 3B type L colony formed on penicillin-containing medium is composed entirely of spherical bodies of varying sizes (2 to 10 ,u in diameter) that appear to propagate by a budding process. In contrast, 3A type L for...

On-line portfolio selection, a fundamental problem in computational finance, has attracted increasing interests from artificial intelligence and machine learning communities in recent years. Empirical evidence shows that stock’s high and low prices are temporary and stock price relatives are likely to follow the mean reversion phenomenon. While existing mean reversion strategies are shown to ac...

We describe several strategies for the calibration of one factor Hull-White model with constant or time-dependent mean reversion and volatility parameters to the interest rate vanillas. We propose an efficient approximation formula for the swaption implied volatility which enables us to estimate the mean reversion independently of the volatility. We give the closed-forms for exact pricing using...

The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naïve major hi...