objectives : platelet preparations are commonly used to enhance bone and soft tissue regeneration. considering the existing controversies on the efficacy of platelet products for tissue regeneration, more in vitro studies are required. the aim of the present study was to compare the in vitro effects of plasma rich in growth factors (prgf) and platelet-rich fibrin (prf) on proliferation and viab...

objective: different techniques have been suggested for the repair of bone defects at the injured sites. use of biomembranes, or application of plasma rich in growth factor (prgf) at the site of proliferation of osteoblasts are among the suggested techniques. the current study aimed to compare the biocompatibility of human periodontal ligament fibroblasts (hplf) cultured on hypro-sorb f, perica...

The potential influence of leukocyte incorporation in the kinetic release of growth factors from platelet-rich plasma (PRP) may explain the conflicting efficiency of leukocyte platelet-rich plasma (L-PRP) scaffolds in tissue regeneration. To assess this hypothesis, leukocyte-free (PRGF-Endoret) and L-PRP fibrin scaffolds were prepared, and both morphogen and proinflammatory cytokine release kin...

Background and aims. A combination of guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and platelet rich plasma has been already applied for the regeneration of intrabony defects. The aim of this study was to determine the role of plasma rich in growth factor (PRGF) alone in the periodontal regeneration of intrabony defects in humans as compared with BPBM/GTR Technique. Mate...

A 42-year-old Mediterranean male presented complaining of inability to sustain good oral care at the posterior aspect of the lower right jaw. The main problems were food impaction in the area and the subsequent malodor. The patient reported remarkable medical history. Clinical examination revealed local erytherma with noticeable bone defect distal to the second molar with obvious defect in the ...

OBJECTIVE The purpose of the present randomized clinical trial study was to compare the effectiveness of Bovine Porous Bone Mineral (BPBM) with and without Plasma Rich in Growth Factors (PRGF) in the treatment of mandibular Class II furcation defects. MATERIALS AND METHODS In seven patients, nine pairs of symmetric buccal or lingual mandibular class II furcation defects were treated. In each ...

BACKGROUND Detection of air cavities, so called pneumatizations, nearby to the temporomandibular joint (TMJ) area is important, as they represent sites of minimal resistance and facilitate the spread of various pathologies into the joint as inflammation, tumor or fractures and serve as a possible complicating factor in TMJ surgery. AIMS To determine the prevalence of pneumatization of the art...

Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an antimicrobial peptide inducibly expressed in human keratinocytes especially upon...