OBJECTIVES We analyzed the clinical features of 138 patients with primary immunodeficiency (PID) and performed genetic testing on a subset of patients in order to complete gaps in research on PID in South China and thus improve pediatricians' ability to recognize and diagnose PID. METHODS We performed a retrospective analysis based on the medical records of PID patients hospitalized in our in...

BACKGROUND Primary immunodeficiency diseases (PID) are heterogeneous group of inherited disorders mainly characterized by recurrent infections leading to several times hospital admissions. The economic impact of PID is a challenging issue; therefore, this study was designed to determine the medical costs of hospitalizations in this group of patients as an indicator of the direct cost of these d...

Primary immunodeficiency diseases (PIDs) represent a large and heterogeneous group of more than 120 different entities, most of which have now been genetically characterized (77). Increased susceptibility to infections is the predominant manifestation of almost all forms of PID, particularly in infants and children, demonstrating the paramount importance of the immune system in defense against ...

immunodeficiency and autoimmune disease may occur concomitantly in the same individual. some of the immunodeficiency syndromes, especially humoral defects are associated with autoimmune disorders. hematological manifestations such as thrombocytopenia and hemolytic anemia are the most common presentations. persistent antigen stimulation due to an inherent defect in the ability of the immune syst...

Primary immunodeficiencies (PID) are traditionally considered childhood diseases; however, adults account for 35% of all patients with PID. Antibody deficiencies, especially Common Variable Immunodeficiency (CVID), which have their peak incidence in adulthood, require a high suspicion index. Even though the estimated frequency of CVID is not high (1:25,000), high rates of under diagnosis and un...

Primary immunodeficiencies (PID) are genetic disorders of immunity whose incidence varies from 1:250 to 1:1,000,000 depending of disease and study population. Because of incomplete records of immunodeficiency in the world, is estimated that the prevalence of 1:5,000 to 1:100,000 (Geha et al., 2007; Boyle & Buckley, 2007; Notarangelo,et al., 2010). Thus, the PID is a important group to public he...

The abstracts that are presented following these individual papers are difficult to evaluate because they do not contain detailed data. However, some interesting results are presented which can be better evaluated when published in full. Examples include a categorization of congenital malformations among births in Puerto Rico, a piece of epidemiologic data not previously available, a presentati...

Anti-cytokines autoantibodies (ACAA) are types of against soluble immune factors and may be mirrored by autoimmune disease biomarkers. The manifestation secretion these antibodies is associated to primary immunodeficiency (PID), but also directly or indirectly related infectious occurrence, which could assumed as a consequence cytokine deficiency