نتایج جستجو برای: primary progressive ms
تعداد نتایج: 862134 فیلتر نتایج به سال:
سابقه و هدف: مالتیپلاسکلروزیس (MS) یک بیماری خودایمنِ همراه با تخریب میلین است. مطالعه های همبستگی ژنتیکی (GAS) تأثیر مستعدکنندگیِ برخی چند شکلیهای تک نوکلئوتیدی (اسنیپ) را در ژن زیر واحد آلفا گیرندۀ اینترلوکین 7 (IL7Ra) برای ابتلا به MS مشخص نموده است که به طور کلی مربوط به کشورهای غربی میباشد. تاکنون گزارشهای اندکی بین ژن IL7Ra و MS در جمعیتهای آسیایی وجود دارد. اسنیپrs11567685 به دل...
Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neuron subset, controls severity and progression of experimental autoimmune encephalomyelitis (EAE) in mice and likely in primary progressive MS. TRPV1-/- B6 c...
BACKGROUND Unusual presentations of multiple sclerosis (MS) at onset may post a diagnostic dilemma to the treating neurologists. Spinal myoclonus is rare in MS and may lead to perform extensive investigations to rule out other etiologies affecting the spinal cord. CASE PRESENTATION We described a 31-year-old male who presented with involuntary brief jerky movements of the left shoulder and ar...
BACKGROUND Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females. METHODS Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analys...
multiple sclerosis (ms) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. the chromosome 19q 13 region surrounding the apolipoprotein e (apoe) gene has shown consistent evidence of involvement in ms. in a cross-sectional study, to show the apoe genotype and allele frequency in the ms population of iran in comparis...
At the present time, anti-inflammatory, immunomodulatory, or immunosuppressive treatments of multiple sclerosis (MS) are mainly effective in the early phases of the disease but are of less advantage in progressive phases. Current therapeutic strategies of both primary and secondary progressive MS are rare. One alternative may be intrathecal application of triamcinolone acetonide (TCA). Number o...
BACKGROUND This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracranial colour Doppler sonography. METHODS We examined 146 MS patients, presenting with a clinically isolated syndrome, relapsing-remitting, secondary progressive, or primary progre...
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