Background: Calotropis gigantea (family: Asclepiadaceae) has been known to contain cardiac glycosides. The C. gigantea extracts have been reported as cytotoxic to a few cancer cell lines. The present study was designed to examine the effect of Calotropis gigantea methanolic extract (CGME) on the growth and apoptosis in human breast carcinoma cell line (MCF-7 cells).Methods: The study was ...

Diffuse large B cell lymphoma (DLBCL) is curable with chemoimmunotherapy in ~65% of patients. One the hallmarks pathogenesis and resistance to therapy DLBCL inhibition apoptosis, which allows malignant cells survive acquire further alterations. Inhibition apoptosis can be result genetic events inhibiting intrinsic or extrinsic apoptotic pathways, as well their modulators, such inhibitor protein...

Abstract Non-small cell lung cancer (NSCLC) is one of the most lethal malignant tumors. It has been shown that general anesthetic agents, propofol and astragaloside IV (AS-IV) both exert antitumor effects in NSCLC. However, combination with AS-IV NSCLC remain unclear. Cell counting kit-8, EdU Transwell assays were performed to evaluate viability, proliferation, migration. apoptosis autophagy ob...

BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation-prone protein. Here, we overcame prior challenges and performed an NMR-based fragment screen of full-length human ...

Resistance to apoptosis is one of the fundamental hallmarks of cancer. Recently, the selective induction of apoptosis in cancer cells has emerged as an exciting possibility for the development of future selective cancer therapy. This review will summarise the development of the major classes of small molecule "pro-apoptotic" antitumour agents.