Despite the profound impact of biologics on the treatment of rheumatoid arthritis (RA), long lasting disease remission remains elusive. We propose that this is a consequence of failing to target the right molecular pathway in the most relevant patient group at the appropriate time and place in disease progression. A limitation to testing this approach is the availability of disease models repre...

6Laboratory for Medicine and Pathology, University of California, San Francisco, San Francisco, California 94143, USA. Navidea Biopharmaceuticals envisages a world where disease can be precisely identified and treated. Today, faced with a multitude of illnesses, millions of people are left with diagnostic uncertainty. As patients and their physicians seek accurate diagnosis of their condition, ...

High-resolution magnetic resonance imaging is emerging as a powerful tool for phenotyping mice in biologic studies of genetic expression, development, and disease progression. In several applications, notably random mutagenesis trials, large cohorts of mice must be examined for abnormalities that may occur in any part of the body. In the aim of establishing a protocol for imaging multiple mice ...

progressive osseous heteroplasia is a rare inherited disease that begins with skin ossification and proceeds into the deeper connective tissues. the disease should be distinguished from other genetic disorders of heterotopic ossification including fibrodysplasia ossificans progressiva (fop) and albright hereditary osteodystrophy (aho). we report a case of progressive osseous heteroplasia in a t...

since the elderly population is increasing rapidly in developing countries which may decrease the physical activity and exercise and in turn could affect the elderly’s quality of life, this study aimed to investigate the effect of progressive muscle relaxation on the elderly’s quality of life in iran. in a randomized clinical trial, participants were randomly divided into intervention and contr...

a 63-year-old woman suffering from progressive systemic sclerosis for about 20 years disclosed symptoms of liver disease within the last three years. diagnosis of biliary cirrhosis was established on the basis of clinical picture, pathological examination of the hepatic tissue sample, immunological tests, and x-ray studies. association of systemic sclerosis with primary biliary cirrhosis is bri...

conclusions the individuals should have multidisciplinary approach for the variety of disorders to maintain the appropriate treatment for a better appearance of the patients. case presentation we describe a patient with progressive hemifacial atrophy at right facial side who developed granulomatous uveitis and periferic retinal vasculitis in his left eye. we started topical and systemic steroid...