Background: To evaluate the safety and efficacy of corneal crosslinking (CXL) treatment in children with keratoconus. Materials Methods:A total 45 eyes 34 progressive keratoconus were included this study. CXL was performed according to conventional method. Manifest refraction, uncorrected distance visual acuity (UDVA), corrected (CDVA), topography values, endothelial cell density (ECD) evaluate...

PURPOSE To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS Patients with progressive keratoconus (n = 205). METHODS The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the e...

A 32-year-old female patient with progressive keratoconus in her right eye was treated with simultaneous customized photoreactive keratoctomy (PRK) and corneal cross-linking (CXL) with riboflavin and Ultraviolet A (UVA) irradiation. Ten days after the procedure, the patient was presented with foreign body sensation, mild ring-shaped corneal infiltration with vascularization at the limbus and Tr...

Keratoconus, a common inherited ocular disorder resulting in progressive corneal thinning, is the leading indication for corneal transplantation in the developed world. Genome-wide association studies have identified common SNPs 100 kb upstream of ZNF469 strongly associated with corneal thickness. Homozygous mutations in ZNF469 and PR domain-containing protein 5 (PRDM5) genes result in brittle ...

This study evaluated the clinical outcomes in keratoconus corneas following accelerated transepithelial corneal collagen cross-linking (CXL) (Avedro KXL® system, Waltham, MA, USA) over one year of follow-up. The mean depth of the demarcation line measured by optical coherence tomography (OCT) was 205.19 µm. One month after surgery, a non-statistically significant change was noted in sphere (P=0...

Keratoconus, a degenerative disorder of the cornea, causes significant visual distortion and photophobia. Diagnosed in early life, it has a considerable influence on the patient’s daily activities and visual needs. A study of the rural population in Central India gave a prevalence of 2.3% +/0.2% among those aged 30 years and above.[1] The conventional treatment of keratoconus has been the fitti...

Purpose To develop an application for the Pentacam HR purpose of optimising accuracy diagnosis progressive keratoconus. Methods Measurements were performed on one randomised eye in twenty-five subjects with keratoconus Stage 1-2 according to Amsler-Krumeich classification two occasions, three days apart. Four replicate measurements made by a single examiner each occasion. The inter-day repeatab...

Five hundred and thirty cases of spring catarrh were studied at the Department of Ophthalmology, Khyber Hospital Peshawar, Pakistan. Corneal complications occurred in 259 patients, of which 48 cases were of keratoconus, consisting of 41 male and seven female patients. Most of the patients affected (37) were between the ages of 10 and 30 years. Six patients developed acute hydrops, which in one ...

THE CONCEPT OF CXL In 1998, the proof-of-principle for corneal collagen cross-linking (CXL) was born from such a “simple” concept. Combining ultraviolet-A light and a chromophore (vitamin B2, riboflavin), the cornea could be stiffened within a mere half hour and progressive thinning diseases such as keratoconus could be halted.1,2 Although still considered a relatively new concept, CXL is now i...