Cotton (Gossypium hirsutum L.) mRNA (H6) is expressed predominantly in fiber cells and is present during early primary cell wall formation. However, H6 protein is found to accumulate during later stages, when active secondary cell wall formation occurs, indicating possible regulation at the translational level and function in the secondary cell wall assembly. The nucleotide-derived amino acid s...

The hemopoietic-specific Gads (Grb2-related adaptor downstream of Shc) adaptor protein possesses amino- and carboxyl-terminal Src homology 3 (SH3) domains flanking a central SH2 domain and a unique region rich in glutamine and proline residues. Gads functions to couple the activated TCR to distal signaling events through its interactions with the leukocyte-specific signaling proteins SLP-76 (SH...

BACKGROUND Specific coupling of de novo designed recombinant protein polymers for the construction of precisely structured nanomaterials is of interest for applications in biomedicine, pharmaceutics and diagnostics. An attractive coupling strategy is to incorporate specifically interacting peptides into the genetic design of the protein polymers. An example of such interaction is the binding of...

Keratinocyte proline-rich protein (KPRP), an epidermal marker expressed in stratified squamous epithelia, is known to be involved skin barrier function. However, the pathological function of KPRP inflammation remains largely unknown. Here we show role Kprp during development imiquimod-induced psoriatic lesions mice. Epidermal thickness and erythema were significantly changed Kprp+/- mice compar...

Synaptojanin (synaptojanin 1) is a recently identified inositol 5'-phosphatase, which is highly enriched in nerve terminals and is implicated in synaptic vesicle recycling. It is composed of three domains: an amino-terminal SacI homology region, a central inositol 5'-phosphatase homology region, and a carboxyl-terminal proline-rich region. We have now identified and characterized a novel form o...

This report describes the physical and chemical properties of a series of proline-rich proteins isolated from parotid glands of isoproterenol-treated rats. As described previously (Muenzer, J., Bildstein, C., Gleason, M., and Carlson, D. M. (1979) J. Biol. Chem. 254, 56235628), a dramatic increase in these proteins occurs concomitantly with hyperplasia and hypertrophy of parotid glands of rats ...