OBJECTIVE Treatment effects to binary endpoints using time-to-event data in randomised controlled trials are typically summarised by reporting HRs derived with Cox proportional hazard models. Alternative and complementary methods include summarising the between-treatment differences on the metric time scale, quantifying the effect as delay of the event (DoE). The aim of this study was to reasse...

When reporting results from survival analysis, investigators often present crude Kaplan-Meier survival curves and adjusted relative hazards from the Cox proportional hazards model. Occasionally, the investigators will also provide a graphical representation of adjusted survival curves based on regression estimates and the average covariate values in the study groups. In this paper, the authors ...

STUDY OBJECTIVES Although many epidemiologic studies have shown that both short and long nighttime sleep durations are associated with increased mortality in the general population, limited data have been reported for older persons, especially those taking afternoon nap. Data from a prospective cohort study of the elderly in Taiwan were used to examine the relationship among nighttime sleep, Ch...

The majority of computational methods applied for the analysis of homogeneous Markov reward models (MRMs) are not applicable for the analysis of inhomogeneous MRMs. By the nature of inhomogeneous models only forward differential equations can be used to describe the model behaviour. In this paper we provide forward partial differential equations describing the distribution of reward measures of...

Methods: AD cases were identified in the Washington Heights Inwood Columbia Aging Project, a longitudinal, community-based study of cognitive aging in Northern Manhattan. The sample comprised 323 participants whowere initially dementia-free but developed AD during study follow-up (incident cases). Participants were followed for an average of 4.1 (up to 12.6) years. Possible factors associated w...

This software fits a multivariate proportional hazards model to interval censored event data by a Bayesian approach. Right and interval censored data and a lognormal or gamma frailty term can be fitted. An example is studied and the output analysed. 1 The basic model The data, based on a sample of size n, consists of the triple (ti, δi,xi), i = 1, . . . , n where ti is the time on study for sub...

Many papers have investigated how personal characteristics and environmental variables affect welfare durations of unmarried mothers. This paper estimates proportional hazard models for welfare durations that allow for either fixed state or fixed labor market area effects. Conditioning on residence location by fixed effects can limit the impact of three types of potential bias. (1) Estimates of...