PRM-151, recombinant human Pentraxin-2 (PTX-2) also referred to as serum amyloid P (SAP), is under development for treatment of fibrosis. A First-in-Human (FIH) trial was performed to assess the safety, tolerability, and pharmacokinetics of single ascending intravenous doses of PRM-151 administered to healthy subjects, using a randomized, blinded, placebo controlled study design. Each cohort in...

The poultry red mite (PRM), Dermanyssus gallinae (De Geer, 1778) (Acari: Dermanyssidae), is a common and significant ectoparasite of the industry worldwide. Although various biological, chemical, physical methods have been attempted, an utterly successful control strategy has not put forward yet. Our experimental investigations observations revealed that ant species Lasius alienus displays effe...

conclusions the present study detected more accurate results for ann method compared to those of cox ph model to analyze the survival of patients with liver transplantation. furthermore, the order of effective factors in patients’ survival after transplantation was clinically more acceptable. the large dataset with a few missing data was the advantage of this study, the fact which makes the res...

Probabilistic RoadMaps (PRMs) are quite successful in solving complex and high-dimensional motion planning problems. While particularly suited for multiple-query scenarios and expansive spaces, they lack efficiency in both solving a small number of queries in an environment and mapping narrow spaces. Two PRM variants separately tackle these gaps. Lazy PRM reduces the computational cost of roadm...

The full-length premembrane (prM) coding region of the dengue virus type 2 (DEN-2; Jamaica) genome was expressed in C6/36 (Aedes albopictus) cells in either the sense or the antisense orientation from a double subgenomic Sindbis (dsSIN) virus. Northern (RNA) blot analysis confirmed the expression of sense or antisense DEN-2 prM RNA in infected C6/36 cells. PrM protein was demonstrated in cells ...

The E-prM proteins of flaviviruses are unusual complexes which play important roles in virus assembly and fusion modulation and in potential immunity-inducing vaccines. Despite their importance, little is known about the biogenesis and structural organization of E-prM complexes. Pulse-chase radiolabeling of dengue virus-infected Vero cells demonstrated a rapid interassociation of E and prM prot...

Cryptosporidium parvum, Tyzzer, 1912 is identified as a common cause of diarrhoea in immunocompetent individuals. In immunocompromised, especially HIV-infected subjects, cryptosporidiosis causes severe chronic diarrhoea. In this study, nitazoxanide (NTZ) was compared for curative activity with sinefungin (SNF) and paromomycin (PRM) in immunosuppressed rats, a screening model for anticryptospori...

Semantic segmentation on Landsat-8 data is crucial in the integration of diverse data, allowing researchers to achieve more productivity and lower expenses. This research aimed improve versatile backbone for dense prediction without convolutions—namely, using pyramid vision transformer (PRM-VS-TM) incorporate attention mechanisms across various feature maps. Furthermore, PRM-VS-TM constructs an...

Cells in the early embryonic vertebrate nervous system are dependent on members of the fibroblast growth factor (FGF) family for their proliferation and subsequent differentiation. These growth factors will only bind to their specific high affinity cell surface receptors after formation of a ternary complex with the glycosaminoglycan heparan sulfate. Such specific heparan sulfates are secreted ...

BACKGROUND The envelope (E) of dengue virus (DENV) is the major target of neutralizing antibodies and vaccine development. After biosynthesis E protein forms a heterodimer with precursor membrane (prM) protein. Recent reports of infection enhancement by anti-prM monoclonal antibodies (mAbs) suggest anti-prM responses could be potentially harmful. Previously, we studied a series of C-terminal tr...