Liver is the main organ which can metabolize many drugs or chemical agents. Toxic events developed by drugs are one of the most common causes of liver damage. Toxic hepatitis can be encountered in different clinical situations, such as acute hepatitis, fulminant hepatitis chronic hepatitis or cirrhosis. We aimed to report a case of asymptomatic toxic hepatitis in a patient taking propylthiourac...

The choice of therapeutic strategies for hyperthyroidism during pregnancy is limited. Surgery and radioiodine are typically avoided, leaving propylthiouracil and methimazole in the US. Carbimazole, a metabolic precursor of methimazole, is available in some countries outside of the US. In the US propylthiouracil is recommended because of concern about developmental toxicity from methimazole and ...

The effects of hypothyroidism on glycogen metabolism in rat skeletal muscle were studied using the perfused rat hindlimb preparation. Three weeks after propylthiouracil treatment, serum thyroxine was undetectable and muscle glycogen and Glc-6-P were decreased. Basal and epinephrine-stimulated phosphorylase a and phosphorylase b kinase activities were also significantly reduced, as were epinephr...

Ce cas clinique présente une patiente de 46 ans déclarant vascularite à ANCA induite par le propylthiouracile. La présentait des polyarthralgies inflammatoires, lésions cutanées ulcérées, un purpura nécrotique, aphtes buccaux, phénomène Raynaud et rhinite inhabituelle, associé positivité au bilan auto-immun avec double spécificité anti-MPO anti-PR3. Une est retrouvée chez 20-64 % patients sous ...

INTRODUCTION There is little information about the risk of HCV recurrence in immunosuppressed patients. Although the presence of antibodies to HCV and the absence of HCV-RNA is usually considered to indicate viral elimination, the virus may not be completely eliminated but may be under control of an effective immune response. CASE PRESENTATION A 69 year old man presented with jaundice, elevat...

* Correspondence: [email protected] Equal contributors Division of Internal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n°1, 98100 Messina, Italy Figure 1 Immunostaining for α-SMA in cutaneous samples. Representative tissue sample from: (A) Sham animal; (B) HOCl mice; (C) HOCl + PTU animal (original magnification, ×40). The arrows sho...

INTRODUCTION Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the fetus. CASE PRESENTATION We report a rare case of fulminant hepatic failure in a 36-year-old gravida 2 black woman of Afric...

A 48 year old white woman was admitted to the hospital because of several bouts of migratory polyarthritis, weight loss, fever, and abdominal pain over a period of 15 months. She had been taking propylthiouracil 100 mg daily for three years for hyperthyroidism treatment. A test for antineutrophil cytoplasmic autoantibodies (ANCA) was positive with a perinuclear pattern of staining. Antiphosphol...