OBJECTIVE Intensive chemotherapy targeting plasma cell dyscrasia has been recently employed for the treatment of primary systemic AL amyloidosis. We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone) in patients with primary systemic AL amyloidosis who were ineligible for high-dose melphalan with autologous stem cell support. PATIENTS AND ...

bioavailability of three rumen protected methionine (met) sources with different protection methods (mepron® m85, evonik industries, germany; methioplus®, soda nutrition, italy and methilock®, tehrandaneh co. iran) were evaluated in 2 experiments with 6 canulated non-lactating holstein cows. in experiment 1, the ruminal in situ and mobile bag techniques were used for assessing ruminal degradabi...

Rates and mechanisms of myoglobin removal from plasma were examined in closed-chest dogs, using disappearance patterns of immunoreactivity and radioactivity after i.v. canine myoglobin radiolabeled with 125I. Arterial immunoreactive myoglobin concentration decreased monoexponentially over a 2-decade range, with rate constants of disappearance averaging -0.080 +/- 0.014 min-1 (+/- SD) (correspon...

The coiled body is a distinct subnuclear domain enriched in small nuclear ribonucleoprotein particles (snRNPs) involved in processing of pre-mRNA. Although the function of the coiled body is still unknown, current models propose that it may have a role in snRNP biogenesis, transport, or recycling. Here we describe that anti-coilin antibodies promote a specific disappearance of the coiled body i...

Plasma vitamin D binding protein (DBP) may scavenge actin released during cell lysis. We examined the plasma disappearance and tissue appearance of 125I-DBP, 125I-G-actin, and the DBP-G-actin complex after their intravenous administration to rats. The plasma disappearance of DBP and DBP-actin were indistinguishable, with rapid initial (t1/2 = 2.6 h) and slower second (t1/2 = 7 h) slopes. After ...

Shifting rats to a protein-free, carbohydrate-rich diet, although not starvation, resulted in the appearance of mRNA for, and activity of, 3-phosphoglycerate dehydrogenase (3-PGDH) in liver as well as in a marked decrease in plasma cystine concentration. Refeeding with protein caused a 50% decrease in the mRNA in 8 h and its complete disappearance within 24 h, followed by a slower disappearance...

An in vitro study was conducted using a 4 • 2 • 2 factorial design with RAC (readily available carbohydrate) levels of 30, 40, 50 and 60%, tallow levels of 0 and 3%, and urea levels of 0 and 2%. Acetic and propionic acid production and ammonia disappearance increased as the level of RAC increased from 30 to 50%. Tallow reduced acetic acid production and increased the amount of propionic acid pr...

Two trials were conducted to investigate the effects of disodium fumarate (DSF; 0.00, 8.00, 10.00 and 12.00 mM) and thyme essential oil (TEO; 0.00, 100.00, 200.00, 300.00 and 400.00 µL L-1) solely and simultaneously (10.00 mM DSF along with 100.00, 200.00, 300.00 and 400 µL L-1 TEO) on in vitro ruminal fermentation of a 50:50 alfalfa hay to concentrate diet. The D...

The use of isotopes has proved to be an important tool in the study of the metlabolism of body constituents (1). The employment of such tracer substan,ces has developed an awareness for easily identifiable substances which can be combined with a particular body constituent, in order to tag it for study purposes. It is understandable, therefore, that the announcement by Rawson(2) that Evans blue...