The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 microm were obtained. The effect of CO(2) and liquid flow, temperature and pressure on particle...

Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. (Zingiberaceae), is shown to have antioxidant, anti-inflammatory, neuroprotective, anxiolytic, and antidepressant properties in both preclinical clinical studies. However, its low bioavailability limitation for potential adoption as therapeutic agent. The process micronization can overcome this barrier by reducing particle si...

High pressure vapor-liquid equilibrium (VLE) of CO2-expanded organic solvents is investigated using Peng-Robinson-LCVM-UNIFAC equation of state. Bubble pressure of ten ternary mixtures is predicted using this mixing rule and correlations are developed based only on binary experimental data. Due to the lack of experimental data for liquid phase density in the literature, it was necessary to perf...

It has been estimated that nearly 35-40 % of drugs suffer from poor aqueous solubility and it affects the absorption of drug from gastrointestinal tract that leads to high inter and intra subject variability, poor oral bioavailability, increase in dose, reduction in therapeutic efficiency and finally failure in formulation development. Various formulation strategies like micronization, solubili...

Eucalyptus wood was micronized chemically with glycol ether in the presence of an acid catalyst. The chemical properties lignin recovered from were investigated to understand behavior components during micronization process. When eucalyptus meals a 3% catalyst, lignocellulosic microfines comprised 47.5% and its Klason content 3.3%. Most eluted using alcohol, acetone, 0.5 N NaOH. Moreover, obtai...