نتایج جستجو برای: proteomics
تعداد نتایج: 30884 فیلتر نتایج به سال:
Proteomics is a leading technology for the high-throughput analysis of proteins on a genome-wide scale. With the completion of genome sequencing projects and the development of analytical methods for protein characterization, proteomics has become a major field of functional genomics. The initial objective of proteomics was the large-scale identification of all protein species in a cell or tiss...
Proteomics emerged in the beginning of the 1990s due to the need for new methods for protein analysis. Proteomics is a much newer discipline than genomics, and confronts similar challenges to those that genomics researchers faced in the implementation of large-scale sequencing programs. The definition of proteomics as the use of quantitative protein-level measurements of gene expression to char...
in genomics, the ability to amplify rare transcripts has enabled rapid advances in the understanding of gene expression patterns in human disease. the inability to increase the copy number and to detect the signal of rare proteins as unique species in biological samples has hindered the ability of proteomics to dissect human disease with the same complexity as genomic analyses. advances in nano...
Recent technological advances have made it possible to identify and quantify thousands of proteins in a single proteomics experiment. As a result of these developments, the analysis of data has become the bottleneck of proteomics experiment. To provide the proteomics community with a user-friendly platform for comprehensive analysis, inspection and visualization of quantitative proteomics data ...
Applications of proteomics tools revolutionized various biomedical disciplines such as genetics, molecular biology, medicine, and dentistry. The aim of this review is to highlight the major milestones in proteomics in dentistry during the last fifteen years. Human oral cavity contains hard and soft tissues and various biofluids including saliva and crevicular fluid. Proteomics has brought revol...
II. Why Functional Proteomics? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 A. The Complementarity of Genomics and Proteomics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 B. Genotypes and Protein Phenotypes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA 2School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK 3Departments of Pharmacology, Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA 4School of Biological Sciences, Nanyang Technological ...
Proteomics has become one of the main approaches for analyzing and understanding biological systems. Yet similar to other high-throughput analysis methods, the presentation of the large amounts of obtained data in easily interpretable ways remains challenging. In this review, we present an overview of the different ways in which proteomics software supports the visualization and interpretation ...
The aim of the ISPIDER project is to create a proteomics grid; that is, a technical platform that supports bioinformaticians in constructing, executing and evaluating in silico analyses of proteomics data. It will be constructed using a combination of generic e-science and Grid technologies, plus proteomics specific components and clients that embody knowledge of the proteomics domain and the a...
This paper focuses on the use of controlled vocabularies (CVs) and ontologies especially in the area of proteomics, primarily related to the work of the Proteomics Standards Initiative (PSI). It describes the relevant proteomics standard formats and the ontologies used within them. Software and tools for working with these ontology files are also discussed. The article also examines the "mappin...
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