Mild hereditary bleeding disorders presenting with mucocutaneous haemorrhages are usually difficult to diagnose. We measured thrombin generation in platelet-poor plasma (TG-PPP) in 206 patients with a clinically unequivocal bleeding tendency: 45 with von Willebrand disease (vWD), 49 with platelet aggregation/secretion defects (PASD), 10 with a combination of both and 102 who did not fit the dia...

INTRODUCTION Bone defects are rather common after oral surgery and may prove difficult to repair. OBJECTIVE We provide a histomorphological analysis of the bone regenerative capacity of platelet-rich plasma at different concentrations and the extraction of platelet-rich bone marrow, compared with beta-tricalcium phosphate. METHODOLOGY We performed an experimental study on 8 pigs, in which w...

objective: at present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-bmp), recombinant platelet derived growth factor and platelet rich plasma (prp) have gained increasing attention. prp is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. prp has gained popularity due to its autolo...

Abstract Introduction Platelet-rich plasma (PRP) has gathered great momentum in surgery. The main outcome of the study was to assess whether there a difference growth factor release from PRP with addition vitamin C, cooling, or both C and cooling. Method Blood samples 10 volunteers were centrifuged produce PRP. Activated autologous thrombin produced platelet-poor (PPP), which added activate it....

  Objective: At present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-BMP), recombinant platelet derived growth factor and platelet rich plasma (PRP) have gained increasing attention. PRP is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. PRP has gained popularity due to its auto...

BACKGROUND Platelet-rich plasma (PRP) has been advocated as one treatment for cartilage tissue regeneration. To date, several different platelet-rich formulations have been available, but a deep knowledge of their composition and mechanism of action in a specific clinical use is needed. The aim of this study was to investigate the effect of various PRP formulations on human chondrocytes in vitr...

Coagulation factor V (FV), present in plasma and platelets, is indispensable to thrombin formation, yet patients with undetectable plasma FV seldom experience major bleeding. We used thrombin generation assays to explore the role of platelet FV in 4 patients with severe congenital FV deficiency (3 with plasma FV clotting activity [FV:C] < 1%). When triggered with tissue factor (TF) concentratio...

BACKGROUND Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions. In particular, TGC in platelet-rich plasma (PRP) can sometimes have two peaks. OBJECTIVE We sought to understand the mechanism underlying the occurrence of two peaks...

a functional treatment for skeletal damages in orthopedic and oral maxillofacial surgeries is required. platelet growth factors such as platelet derived growth factor (pdgf), bone morphogenic factor (bmp), transferring growth factor-β (tgf-β) and insulin-like growth factor-1 (igf-1) proceed wound healing and bone regeneration. in the present study we focused on the effect of platelet rich plasm...

Although platelet-rich plasma (PRP) is the plasma fraction that contains higher levels of platelet-sequestered proteins such as growth factors and chemokines, it is also abundant in bioactive lipids whose role in wound healing has not been well characterized. This study provides a preliminary evaluation for the effect of the lipid component of PRP on selected genes related to wound healing. Spr...