نتایج جستجو برای: pseudoexfoliation syndrome pex
تعداد نتایج: 622509 فیلتر نتایج به سال:
PURPOSE To identify and characterize genes differentially expressed in anterior segment tissues of eyes with pseudoexfoliation (PEX) syndrome and glaucoma. METHODS Anterior segment tissues (iris, ciliary processes, lens epithelium) were obtained from eight surgically enucleated eyes with PEX-associated open-angle or closed-angle glaucomas and eight age-matched glaucomatous control eyes withou...
Pseudoexfoliation (PEX) syndrome is an age-related systemic disease with primarily ocular manifestations characterized by deposition of whitish-gray pseudoexfoliation fibrillogranular amyloid like material on the anterior lens capsule, zonules, ciliary body, pupillary margin of the iris, corneal endothelium, anterior vitreous and trabecular meshwork [1,2]. The most important and easily recogniz...
PURPOSE To investigate the aqueous humor, lens, and serum concentrations of zinc, iron, and copper in patients with pseudoexfoliative cataract and compare with patients who have senile cataract without pseudoexfoliation. METHODS Twenty-five patients with pseudoexfoliative cataract and 25 patients with senile cataract as control group were enrolled in the study. Samples from aqueous humor, ser...
PURPOSE Three common sequence variants in the lysyl oxidase-like 1 (LOXL1) gene were recently associated with pseudoexfoliation (PEX) and pseudoexfoliation glaucoma (PEXG) in populations from various parts of the world. In this study, the genetic association of these variants was investigated in Greek patients with PEX and PEXG. METHODS The three LOXL1 single nucleotide polymorphisms (SNPs), ...
PURPOSE To quantify the morphological alterations in corneal nerve fibers and cells in patients with pseudoexfoliation syndrome (PEX) and their relationship with the presence of hyperreflective endothelial deposits observed using in vivo confocal microscopy. METHODS One eye each of 37 patients with PEX and 20 age-matched healthy control subjects was evaluated by in vivo corneal confocal micro...
PURPOSE To investigate the possible association between tumor necrosis factor alpha (TNF-alpha)-308 G/A polymorphism and pseudoexfoliation (PEX) glaucoma. METHODS One hundred and ten Turkish PEX glaucoma patients and 110 healthy control subjects were enrolled in the study. All participants underwent a complete ophthalmic examination. TNF-alpha-308 was genotyped by polymerase chain reaction an...
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular complications, no functional variants have been identified to date. Here, we conduct a genome-wide association scan on 771 German PEX patients and 1,350 controls, followed by independent testing of associated variants in Italian a...
Cataract is a common disease of the eye and cataract development is usually a very gradual process of normal aging. Many people with cataract disease can also have pseudoexfoliation (PEX) syndrome, glaucoma and coronary artery disease (CHD). We use the data from the Department of Ophthalmology, Medical School of the University of Patras, Greece. These data contains 2140 Greek patients from the ...
OBJECTIVES To compare anterior chamber depth (ACD) changes after phacoemulsification surgery in patients with pseudoexfoliation syndrome (PEX) and normal patients using an anterior segment imaging method. Another aim of this study was to evaluate the effect of these changes on the accuracy of intraocular lens (IOL) power calculation and postoperative refraction. MATERIALS AND METHODS Twenty-t...
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