County, Denmark, blood samples were drawn in the fasting state at 8 a.m. for determination of serum levels of calcium, protein, cholesterol, and triglyceride. The serum calcium levels were corrected to a constant serum protein level.2 All determinations were made in duplicate, and the coefficients of variation (C.V.) of duplicate measurements and the mean values and standard deviations (S.D.) a...

To the Editors: Clozapine is a tricyclic dibenzodiazepine derivative, atypical antipsychotic which exhibits relatively potent antiserotonergic (5-HT2, 5-HT3), antialpha1 adrenergic, antihistaminic (H1), antimuscarinic activity, and induces preferential blockade of dopamine D1 and D4 receptors in vivo. 2–4 Various adverse gastrointestinal effects have been associated with its use including const...

A case of fatal pseudomembranous enterocolitis associated with ampicillin therapy is described and possible mechanisms for its production discussed.

A 67-year-old man with a history of low anterior resection and diverting loop transverse colostomy for rectal carcinoma developed fulminant pseudomembranous colitis after stoma closure. Oral administration of vancomycin at 0.5 g every 6 h and colonoscopy with intracolic vancomycin administration was unsuccessful, but continuation of intracolic vancomycin with postural change resulted in dramati...

An 80-year-old woman was admitted to hospital with a fractured neck of the femur, which was managed by internal fixation. Antibiotic cover was not provided for the operation. On the sixth day after operation she developed a fever, which was clinically attributed to a urinary infection, although no organism was subsequently cultured. Treatment was started with cotrimoxazole (Septrin), two tablet...