Purpose: Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explore the benefits of microemulsion formulation as oral drug delivery system for immediate release to improve the bioavailability and efficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The opt...

Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μg/ml). The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral absorption of OLM. The solubility of OLM in various oils, surf...

In this study, a thermosensitive in situ gel nanoemulsion was formulated by low energy method for intranasal delivery of temozolomide to bypass the blood-brain barrier and optimize chemotherapy glioblastoma. Various amounts Labrasol, Transcutol®P, Triacetin were chosen as components based on solubility partial pseudoternary phase diagrams studies. Poloxamer derivatives added selected gelling te...

Treatment of Psoriasis Abstract Mycophenolate mofetil (MMF), the morpholinoethyl ester of mycophenolic acid is an immunosuppressive agent used to prevent organ rejection after kidney and heart transplant. The drug seem to be effective in dermal diseases mainly psoriasis. However, till date it can be only be administered using systemic route which is often associated with side effects such as na...