The word prion was coined by Nobel laureate Stanley Prusiner to describe the infectious agent in a group of fatal neurodegenerative diseases that includes scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt-Jakob disease (vCJD) in humans. The infectious agent is a misfolded form of the protein, PrP, denoted PrPSc, which forms polymers that grow by recruiti...

We provide an overview of the design of PSI (“a Private data Sharing Interface”), a system we are developing to enable researchers in the social sciences and other fields to share and explore privacy-sensitive datasets with the strong privacy protections of differential privacy. ∗This work is part of the “Privacy Tools for Sharing Research Data” project at Harvard, supported by NSF grant CNS-12...

This study proposes modifications to an existing automatic classification method of Persistent Scatterers Interferometry (PSI) time series (TS) and a new procedure classify ground movements into seven classes. We also represent technique detect TSs affected by phase unwrapping errors reclassification part stable points, which are incorrectly classified as moving points using the original method...

The cyanobacterial PSI complex is a membrane-bound, photooxidoreductase that catalyzes the light-driven transport of electrons from reduced plastocyanin (or Cyt cSs3) to oxidized, soluble Fd or flavodoxin (for a review, see Golbeck and Bryant, 1991). The complex probably comprises single copies of 11 or 12 different polypeptides, about 100 Chl a molecules, 10 to 15 p-carotene molecules, 2 molec...

The development of chemically stable porous silicon (pSi) materials for DIOS (Desorption/Ionization on Silicon) mass spectrometry, covalent linkers cleaved in the DIOS laser pulse, and efficient methods for bond formation to immobilized species, allows for on-chip affinity purification and mass detection.

let $g$ be a finite group‎. ‎we denote by $psi(g)$ the integer $sum_{gin g}o(g)$‎, ‎where $o(g)$ denotes the order of $g in g$‎. ‎here we show that‎ ‎$psi(a_5)< psi(g)$ for every non-simple group $g$ of order $60$‎, ‎where $a_5$ is the alternating group of degree $5$‎. ‎also we prove that $psi(psl(2,7))

All-atom molecular dynamics (MD) simulation was used to study the solution dynamics and protein-protein interactions of protein fusions of photosystem I (PSI) from Thermosynechococcus elongatus and an [FeFe]-hydrogenase (FeFe H2ase) from Clostridium pasteurianum, a unique complex capable of photocatalytic hydrogen production. This study involved fusions of these two proteins via dithiol linkers...

In this work, a Glycyl-Histidyl-Glycyl-Histidine (GlyHisGlyHis) peptide is covalently anchored to the porous silicon PSi surface using a multi-step reaction scheme compatible with the mild conditions required for preserving the probe activity. In a first step, alkene precursors are grafted onto the hydrogenated PSi surface using the hydrosilylation route, allowing for the formation of a carboxy...

Conformational energies, consisting of nonbonded and electrostatic interactions, have been calculated for poly(L-proline) I and II helices, of six-residues length, with a water molecule hydrogen-bonded to each imide group. For polyproline I, the Traub-Shmueli prolyl-ring geometry was used, whereas for polyproline II, calculations were done for the 2 ring geometries of Leung and Marsh and, in so...