Overcoming the resistance of tumours to chemotherapy, often due to downregulation of Bax and Bak, represents a significant clinical challenge. It is therefore important to identify novel apoptosis inducers that bypass Bax and Bak. Potassium channels are emerging as oncological targets and a crucial role of mitochondrial Kv1.3 in apoptosis has been demonstrated. Here we report for the first time...

The phylogeny of the family Micareaceae and the genus Micarea was studied using mitochondrial small subunit ribosomal DNA sequences. Phylogenetic reconstructions were performed using Bayesian MCMC tree sampling and a maximum likelihood approach. The Micareaceae in its current sense is highly heterogeneous, and Helocarpon, Psilolechia, and Scutula, all thought to be close relatives of Micarea, a...

The large field of the Materia Medica showed many different remedies, different in characters. However, HAHNEMANN was most impressed by particular diseases, which required particular attention. The destructive elements of syphilis became apparent. At this time, during the Napoleon wars, syphilis spread quickly over Europe and could be studied very well. The character of syphilis was an object o...

Kv1.3 is a voltage-gated K(+) channel expressed in insulin-sensitive tissues. We previously showed that gene inactivation or pharmacological inhibition of Kv1.3 channel activity increased peripheral insulin sensitivity independently of body weight by augmenting the amount of GLUT4 at the plasma membrane. In the present study, we further examined the effect Kv1.3 on GLUT4 trafficking and tested ...

Introduction: Over the years, newly introduced anti-psoriatic treatments have provided excellent treatment response to a large number of patients in clinical trials. We analyzed which extent this has led an overall improvement real-world patient cohort Austrian Psoriasis Registry (PsoRA). Methods: Patient characteristics and effectiveness terms PASI responses were biologic-naïve during first ye...

Fur color that differs from the typical shades of brown and gray occurs in eight species of marmots. Albinism generally is rare whereas melanism is more common. Melanism may persist in some populations at low frequencies averaging 16.1% in M. monax and in M. flaviventris for as long as 80 years. White (not albino) and “bluish” marmots generally are rare, but a population of white M. marmota per...