Background: Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. The expression of N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in CRC. The aim of this study was to investigate the effect of NDRG2 overexpression on cell proliferation and invasive potential of SW48 cells.Methods: SW48 cells were transfected with a plasmid overexpressing ND...

METHODS. cDNA encoding Pdlim2 was identified in a cDNA library of transcripts expressed in the tissues of the rat eye irido-corneal angle. The expression pattern of the Pdlim2 gene was studied by Northern blot analysis and in situ hybridization. Proteins interacting with Pdlim2 were identified by pull-down assay and mass spectrometry. Intracellular localization of Pdlim2 was investigated by con...

background and objectives: datura innoxiamilleris one of the two species of datura (solanaceae) which grow in iran. there are many reports of the biological activities of datura and in the present study the ability of datura innoxia for inhibiting angiogenesis was evaluated. methods: the methanol extract and petroleum ether, chloroform and methanol fractions of datura innoxia flowers were obtai...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

introduction: the aim of this study was to evaluate the cytotoxicity of a new nano zinc-oxide eugenol (nzoe) sealer in comparison with ah-26 and pulpdent root canal sealers. methods and materials: the l929 mouse fibroblast cells were cultivated and incubated for 24, 48 or 72 h with different dilutions (1/1, 1/2, 1/4, 1/8, 1/16 and 1/32) of culture media previously exposed to either of the test ...

objective(s) annual incidence of cutaneous leishmaniasis is increasingly growing and development of the alternative drugs against it is a major concern. artemisia genus is a traditional medicinal plant in iran. the aim of this study was to examine the leishmanicidal activity of various iranian artemisia species extracts. materials and methods different extracts were gathered from eleven iranian...

background and objectives: otostegia persica (burm.) boiss. is an endemic plant of iran with various applications in traditional medicine which contains of several antioxidant constituents. this research was aimed to investigate the effect of hydroalcoholic extract from o. persica aerial parts in human umbilical vein endothelial cells (huvecs) using hydrogen peroxide (h2o2) as an inducer of oxi...

extracts derived from viscum album have been shown to kill cancer cells in vitro. some studies have noted that different species of this plant collected from around the world displayed cytotoxic effects in different extents. in the present study, we evaluated the effects of iranian mistletoe extracts on five cancer cell lines. plants growing on hornbeam tree (carpinus betulus) were collected, a...

BACKGROUND DNA methylation is an epigenetic modification that plays a crucial role in a variety of biological processes. Methylated DNA is specifically bound by Methyl-CpG Binding Proteins (MBPs). Three different types of MBPs have been identified so far: the Methyl-CpG Binding Domain (MBD) family proteins, three BTB/POZ-Zn-finger proteins, and UHRF1. Most of the known MBPs have been identified...