according to Gordon Mills, M.D., Ph.D., chair of molecular oncology at the M. D. Anderson Cancer Center in Houston. “I’d describe it as a technical tour de force,” said Mills, who was not involved in the work. “It refi nes our understanding of the mechanism by which BRCA2 coordinates DNA repair, and it could have a massive impact on developing new ways to go after abnormalities in both BRCA1 an...

abstract in order to study the effects of salinity and silicon application on biomass of leaves and root of purslane (portulaca oleracea l.), a greenhouse experiment was conducted at research greenhouse of ferdowsi university of mashhad using completely randomized desgin with three replications. employed two factors consisted of three levels of salinity using nacl (0.6, 11, 22 ds/m) and two lev...

Objective A highly sensitive and specifi c analytical method was developed for the qualitative and quantitative analysis of clonazepam (CLOZ) and its metabolite 7-aminoclonazepam (7-AC) in blood. The analytes were identifi ed by automated solid phase extraction-liquid chromatography-tandem quadrupole time-of-fl ight mass spectrometry (ASPELC-QTOF/MS) and quantitatively determined by automated s...

The enzyme of rat liver that can transform /V-hydroxy-/V2-fluorenyIacetamide into a reactive derivative capable of introducing fluorenylamine groups into nucleic acids has been shown to be a sulfhydryl-dependent enzyme with a molecular weight of approximately 28,000. A 30-fold purifi cation of the enzyme from 105,000 x g supernatants of liver has been achieved by precipitation with ammonium sul...

To the Editor: In response to a recent report that suggested human infection with Rickettsia japonica in northeastern Thailand (1), we phylogenetically reexamined spotted fever group rickettsiae (SFGR) from Thailand. The organism had been isolated from a male Haemaphysalis hystricis tick found on Mt. Doi Suthep, Chiang Mai, northern Thailand, in December 2001. The strain was designated TCM1 and...

It has long been known that complex interactions occur between tumors and normal host immune cells. The human melanoma cell line A375 has been used previously as an indicator cell for tumor cell cytotoxicity mediated by monocytes. During other studies on this tumor cell line, we noted that the conditioned media harvested from A375 cultures induced both the human monocytoid cell line U937 and hu...

Background: In recent years, nanomaterials have been widely used in large quantities which make people be more frequently exposed to the chemically synthesized nanoparticles (NPs). When NPs are introduced into an organism, they may interact with a variety of cellular components with yet largely unknown pathological consequences. Objective: It was found that NPs enhance the rate of protein fi br...

Flavivirus reveals its access code Fritz et al. have identifi ed an amino acid switch that fl aviviruses fl ip to gain access to cells. Flaviviruses such as tick-borne encephalitis virus (TBEV), yellow fever, and dengue are dangerous human pathogens. These membrane-encircled viruses enter cells by being gobbled up into endosomes and fusing their membrane with that of the endosome. Fusion is tri...